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Integrative analysis of sex differences in the rapid antidepressant effects of ketamine in preclinical models for individualized clinical outcomes.

Title: Integrative analysis of sex differences in the rapid antidepressant effects of ketamine in preclinical models for individualized clinical outcomes.
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Name(s): Saland, Samantha K, author
Duclot, Florian, author
Kabbaj, Mohamed, author
Type of Resource: text
Genre: Journal Article
Text
Date Issued: 2017-04-01
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: In major depressive disorder, women exhibit higher lifetime prevalence and different antidepressant response rates than men, which illustrates the importance of examining individual differences in the pathophysiology of depression and therapeutic response. In recent years, the consideration of sex in related preclinical research has thus gained interest-particularly in light of novel evidence for rapid-acting antidepressants. Notably, the literature recently revealed a higher sensitivity of females to the antidepressant effects of the N-methyl-D-aspartate receptor antagonist ketamine, in both baseline and preclinical conditions. Combined with its fast-acting and relatively sustained properties, this evidence highlights ketamine as a particularly interesting therapeutic alternative for this sensitive population, and supports the value in considering sex as a critical factor for improved individualized therapeutic strategies.
Identifier: FSU_pmch_28584860 (IID), 10.1016/j.cobeha.2016.11.002 (DOI), PMC5456295 (PMCID), 28584860 (RID), 28584860 (EID)
Grant Number: R01 MH087583, R01 MH099085
Publication Note: This NIH-funded author manuscript originally appeared in PubMed Central at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5456295.
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_pmch_28584860
Owner Institution: FSU
Is Part Of: Current opinion in behavioral sciences.
2352-1546
Issue: vol. 14

Choose the citation style.
Saland, S. K., Duclot, F., & Kabbaj, M. (2017). Integrative analysis of sex differences in the rapid antidepressant effects of ketamine in preclinical models for individualized clinical outcomes. Current Opinion In Behavioral Sciences. Retrieved from http://purl.flvc.org/fsu/fd/FSU_pmch_28584860