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Liraglutide suppression of caloric intake competes with the intake-promoting effects of a palatable cafeteria diet, but does not impact food or macronutrient selection.

Title: Liraglutide suppression of caloric intake competes with the intake-promoting effects of a palatable cafeteria diet, but does not impact food or macronutrient selection.
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Name(s): Hyde, Kellie M, author
Blonde, Ginger D, author
le Roux, Carel W, author
Spector, Alan C, author
Type of Resource: text
Genre: Journal Article
Text
Date Issued: 2017-08-01
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: Liraglutide, a Glucagon-Like Peptide-1 (GLP-1) receptor agonist, is used as a treatment for Type 2 diabetes mellitus and obesity because it improves glycemia and decreases food intake. Here, we tested whether chronic activation of the GLP-1 receptor system with liraglutide would induce decreases in intake accompanied by changes in proportional food or macronutrient intake similar to those seen following RYGB in rats when a variety of palatable food options are available. A "cafeteria diet" was used that included: laboratory rodent chow, refried beans (low-fat/low-sugar), low-fat yogurt (low-fat/high-sugar), peanut butter (high-fat/low-sugar) and sugar-fat whip (high-fat/high-sugar). Liraglutide (1mg/kg daily, sc, n=6) induced significant reductions in body weight and total caloric intake compared to saline-injected control rats (n=6). Although access to a cafeteria diet induced increases in caloric intake in both groups relative to chow alone, liraglutide still effectively decreased intake compared with saline-injected rats suggesting that chronic GLP-1 activation competes with the energy density and palatability of available food options in modulating ingestive behavior. Even with the substantial effects on overall intake, liraglutide did not change food choice or relative macronutrient intake when compared to pre-treatment baseline. When drug treatment was discontinued, the liraglutide group increased caloric intake and rapidly gained body weight to match that of the saline group. These results demonstrate that, while liraglutide effectively decreases caloric intake and body weight in rats, it does not cause adjustments in relative macronutrient consumption. Our data also show that drug-induced decreases in intake and body weight are not maintained following termination of treatment.
Identifier: FSU_pmch_28366815 (IID), 10.1016/j.physbeh.2017.03.045 (DOI), PMC5545097 (PMCID), 28366815 (RID), 28366815 (EID), S0031-9384(16)31043-5 (PII)
Keywords: Food choice, GLP-1, Roux-en-Y gastric bypass, Taste preference, Weight loss
Grant Number: R21 DC012751
Publication Note: This NIH-funded author manuscript originally appeared in PubMed Central at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5545097.
Subject(s): Analysis of Variance
Animal Feed
Animals
Anti-Obesity Agents/pharmacology
Body Weight/drug effects
Dietary Carbohydrates
Dietary Fats
Dietary Proteins
Energy Intake/drug effects
Food Preferences/drug effects
Glucagon-Like Peptide-1 Receptor/agonists
Liraglutide/pharmacology
Male
Rats, Sprague-Dawley
Time Factors
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_pmch_28366815
Owner Institution: FSU
Is Part Of: Physiology & behavior.
1873-507X
Issue: vol. 177

Choose the citation style.
Hyde, K. M., Blonde, G. D., Le Roux, C. W., & Spector, A. C. (2017). Liraglutide suppression of caloric intake competes with the intake-promoting effects of a palatable cafeteria diet, but does not impact food or macronutrient selection. Physiology & Behavior. Retrieved from http://purl.flvc.org/fsu/fd/FSU_pmch_28366815