You are here

Review about gabapentin misuse, interactions, contraindications and side effects.

Title: Review about gabapentin misuse, interactions, contraindications and side effects.
1 views
0 downloads
Name(s): Quintero, Gabriel C, author
Type of Resource: text
Genre: Journal Article
Text
Date Issued: 2017-02-09
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: The current work is targeted to review the risks of gabapentin misuse, its potential interactions with other drugs, side effects and use contraindications. This review consists of a total of 99 biographical references (from the year 1983 to 2016). A publication search of PubMed was performed from January 1983 to December 2016. It included animal studies, clinical studies, case studies and reviews related to gabapentin misuse, potential interactions, side effects and use contraindications. The search terms were gabapentin, anticonvulsant and antiepileptic. In general, it seems that gabapentin has risks of being misused based on the increased level of prescriptions, related fatalities, recreational misuse and higher doses of self-administration. The main reasons for gabapentin misuse are as follows: getting high, alleviating opioid withdrawal symptoms and potentiating methadone effects. Some of the main substances that interact with gabapentin are morphine, caffeine, losartan, ethacrynic acid, phenytoin, mefloquine and magnesium oxide. Some of the side effects caused by gabapentin are teratogenicity, hypoventilation, respiratory failure and myopathy. Finally, reports in general contraindicate the use of gabapentin in conditions such as myasthenia gravis and myoclonus.
Identifier: FSU_pmch_28223849 (IID), 10.2147/JEP.S124391 (DOI), PMC5308580 (PMCID), 28223849 (RID), 28223849 (EID), jep-9-013 (PII)
Keywords: Contraindications, Gabapentin, Interactions, Misuse, Side effects
Publication Note: This NIH-funded author manuscript originally appeared in PubMed Central at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5308580.
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_pmch_28223849
Owner Institution: FSU
Is Part Of: Journal of experimental pharmacology.
1179-1454
Issue: vol. 9

Choose the citation style.
Quintero, G. C. (2017). Review about gabapentin misuse, interactions, contraindications and side effects. Journal Of Experimental Pharmacology. Retrieved from http://purl.flvc.org/fsu/fd/FSU_pmch_28223849