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Integrative Comparison of mRNA Expression Patterns in Breast Cancers from Caucasian and Asian Americans with Implications for Precision Medicine.

Title: Integrative Comparison of mRNA Expression Patterns in Breast Cancers from Caucasian and Asian Americans with Implications for Precision Medicine.
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Name(s): Shi, Yanxia, author
Steppi, Albert, author
Cao, Ye, author
Wang, Jianan, author
He, Max M, author
Li, Liren, author
Zhang, Jinfeng, author
Type of Resource: text
Genre: Journal Article
Text
Date Issued: 2017-01-15
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: Asian Americans (AS) have significantly lower incidence and mortality rates of breast cancer than Caucasian Americans (CA). Although this racial disparity has been documented, the underlying pathogenetic factors explaining it are obscure. We addressed this issue by an integrative genomics approach to compare mRNA expression between AS and CA cases of breast cancer. RNA-seq data from the Cancer Genome Atlas showed that mRNA expression revealed significant differences at gene and pathway levels. Increased susceptibility and severity in CA patients were likely the result of synergistic environmental and genetic risk factors, with arachidonic acid metabolism and PPAR signaling pathways implicated in linking environmental and genetic factors. An analysis that also added eQTL data from the Genotype-Tissue Expression Project and SNP data from the 1,000 Genomes Project identified several SNPs associated with differentially expressed genes. Overall, the associations we identified may enable a more focused study of genotypic differences that may help explain the disparity in breast cancer incidence and mortality rates in CA and AS populations and inform precision medicine. Cancer Res; 77(2); 423-33. ©2016 AACR.
Identifier: FSU_pmch_28069798 (IID), 10.1158/0008-5472.CAN-16-1959 (DOI), PMC5243181 (PMCID), 28069798 (RID), 28069798 (EID)
Grant Number: R21 GM101552, UL1 TR000427
Publication Note: This NIH-funded author manuscript originally appeared in PubMed Central at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5243181.
Subject(s): Adult
Aged
Asian Americans/genetics
Breast Neoplasms/ethnology
Breast Neoplasms/genetics
European Continental Ancestry Group/genetics
Female
Gene Expression Profiling
Gene Regulatory Networks
Genetic Predisposition to Disease
Genome-Wide Association Study
Genotype
High-Throughput Nucleotide Sequencing
Humans
Middle Aged
Polymorphism, Single Nucleotide
Precision Medicine/methods
RNA, Messenger/analysis
RNA, Messenger/genetics
Transcriptome
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_pmch_28069798
Owner Institution: FSU
Is Part Of: Cancer research.
1538-7445
Issue: iss. 2, vol. 77

Choose the citation style.
Shi, Y., Steppi, A., Cao, Y., Wang, J., He, M. M., Li, L., & Zhang, J. (2017). Integrative Comparison of mRNA Expression Patterns in Breast Cancers from Caucasian and Asian Americans with Implications for Precision Medicine. Cancer Research. Retrieved from http://purl.flvc.org/fsu/fd/FSU_pmch_28069798