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Role of proteasome-dependent protein degradation in long-term operant memory in Aplysia.

Title: Role of proteasome-dependent protein degradation in long-term operant memory in Aplysia.
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Name(s): Lyons, Lisa C, author
Gardner, Jacob S, author
Gandour, Catherine E, author
Krishnan, Harini C, author
Type of Resource: text
Genre: Journal Article
Text
Date Issued: 2016-12-15
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: We investigated the in vivo role of protein degradation during intermediate (ITM) and long-term memory (LTM) in Aplysia using an operant learning paradigm. The proteasome inhibitor MG-132 inhibited the induction and molecular consolidation of LTM with no effect on ITM. Remarkably, maintenance of steady-state protein levels through inhibition of protein synthesis using either anisomycin or rapamycin in conjunction with proteasome inhibition permitted the formation of robust 24 h LTM. Our studies suggest a primary role for proteasomal activity in facilitation of gene transcription for LTM and raise the possibility that synaptic mechanisms are sufficient to sustain 24 h memory.
Identifier: FSU_pmch_27980077 (IID), 10.1101/lm.043794.116 (DOI), PMC5159658 (PMCID), 27980077 (RID), 27980077 (EID), 24/1/59 (PII)
Grant Number: R01 MH081012, R21 NS088835
Publication Note: This NIH-funded author manuscript originally appeared in PubMed Central at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5159658.
Subject(s): Analysis of Variance
Animals
Anisomycin/pharmacology
Aplysia/drug effects
Aplysia/physiology
Conditioning, Operant/drug effects
Conditioning, Operant/physiology
Cysteine Proteinase Inhibitors/pharmacology
Leupeptins/pharmacology
Memory, Long-Term/drug effects
Memory, Long-Term/physiology
Proteasome Endopeptidase Complex/drug effects
Proteasome Endopeptidase Complex/metabolism
Time Factors
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_pmch_27980077
Owner Institution: FSU
Is Part Of: Learning & memory (Cold Spring Harbor, N.Y.).
1549-5485
Issue: iss. 1, vol. 24

Choose the citation style.
Lyons, L. C., Gardner, J. S., Gandour, C. E., & Krishnan, H. C. (2016). Role of proteasome-dependent protein degradation in long-term operant memory in Aplysia. Learning & Memory (Cold Spring Harbor, N.y.). Retrieved from http://purl.flvc.org/fsu/fd/FSU_pmch_27980077