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Pleiotropy, constraint, and modularity in the evolution of life histories

Title: Pleiotropy, constraint, and modularity in the evolution of life histories: insights from genomic analyses.
Name(s): Hughes, Kimberly A, author
Leips, Jeff, author
Type of Resource: text
Genre: Journal Article
Date Issued: 2017-02-01
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: Multicellular organisms display an enormous range of life history (LH) strategies and present an evolutionary conundrum; despite strong natural selection, LH traits are characterized by high levels of genetic variation. To understand the evolution of life histories and maintenance of this variation, the specific phenotypic effects of segregating alleles and the genetic networks in which they act need to be elucidated. In particular, the extent to which LH evolution is constrained by the pleiotropy of alleles contributing to LH variation is generally unknown. Here, we review recent empirical results that shed light on this question, with an emphasis on studies employing genomic analyses. While genome-scale analyses are increasingly practical and affordable, they face limitations of genetic resolution and statistical power. We describe new research approaches that we believe can produce new insights and evaluate their promise and applicability to different kinds of organisms. Two approaches seem particularly promising: experiments that manipulate selection in multiple dimensions and measure phenotypic and genomic response and analytical approaches that take into account genome-wide associations between markers and phenotypes, rather than applying a traditional marker-by-marker approach.
Identifier: FSU_pmch_27936291 (IID), 10.1111/nyas.13256 (DOI), PMC5318229 (PMCID), 27936291 (RID), 27936291 (EID)
Keywords: GWAS, QTL, Age-specific variation, Population genomics, Trade-off
Grant Number: F32 GM016990, R01 DK084219
Publication Note: This NIH-funded author manuscript originally appeared in PubMed Central at
Subject(s): Animals
Biological Evolution
Drosophila melanogaster
Genetic Pleiotropy
Genetic Variation
Genetics, Population
Genome-Wide Association Study
Quantitative Trait Loci
Selection, Genetic
Persistent Link to This Record:
Owner Institution: FSU
Is Part Of: Annals of the New York Academy of Sciences.
Issue: iss. 1, vol. 1389

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Hughes, K. A., & Leips, J. (2017). Pleiotropy, constraint, and modularity in the evolution of life histories: insights from genomic analyses. Annals Of The New York Academy Of Sciences. Retrieved from