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effects of a multi-ingredient supplement on markers of muscle damage and inflammation following downhill running in females.

Title: The effects of a multi-ingredient supplement on markers of muscle damage and inflammation following downhill running in females.
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Name(s): Köhne, Jessica L, author
Ormsbee, Michael J, author
McKune, Andrew J, author
Type of Resource: text
Genre: Journal Article
Text
Date Issued: 2016-11-25
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: The effects of a multi-ingredient performance supplement (MIPS) on markers of inflammation and muscle damage, perceived soreness and lower limb performance are unknown in endurance-trained female athletes. The purpose of this study was to determine the impact of MIPS (NO-Shotgun®) pre-loaded 4 weeks prior to a single-bout of downhill running (DHR) on hsC-Reactive Protein (hsCRP), interleukin (IL)-6, creatine kinase (CK), muscle soreness, lower limb circumferences and performance. Trained female runners ( = 8; 29 ± 5.9 years) (VO: ≥ 50 ml.kg.min, midfollicular phase (7-11 days post-menses) were randomly assigned in a double-blind manner into two groups: MIPS ( = 4) ingested one serving of NO Shotgun daily for 28 days prior to DHR and 30 min prior to all post-testing visits; Control (CON) ( = 4) consumed an isocaloric maltodextrin placebo in an identical manner to MIPS. hsCRP, IL-6, CK, perceived soreness, limb circumferences, and performance measures (flexibility, squat jump peak power) were tested on 5 occasions; immediately before (PRE), immediately post-DHR, 24, 48 and 72 h post-DHR. There were main effects of time for CK ( = 0.05), pain pressure threshold (right tibialis anterior ( = 0.010), right biceps femoris ( = 0.01), and left iliotibial band (ITB) ( = 0.05) across all time points), and maximum squat jump power ( = 0.04). Compared with 24 h post-DHR, maximum squat jump power was significantly lower at 48 h post-DHR ( = 0.05). Lower body perceived soreness was significantly increased at 24 h ( = 0.02) and baseline to 48 h ( = 0.02) post DHR. IL-6 peaked immediately post-DHR ( = 0.03) and hsCRP peaked at 24 h post-DHR ( = 0.06). Calculation of effect sizes indicated a moderate attenuation of hsCRP in MIPS at 72 h post-DHR. Consumption of MIPS for 4 weeks prior to a single bout of DHR attenuated inflammation three days post, but did not affect perceived soreness and muscle damage markers in endurance trained female runners following a single bout of DHR.
Identifier: FSU_pmch_27924138 (IID), 10.1186/s12970-016-0156-5 (DOI), PMC5123227 (PMCID), 27924138 (RID), 27924138 (EID), 156 (PII)
Keywords: Eccentric exercise, Muscle soreness, Recovery
Publication Note: This NIH-funded author manuscript originally appeared in PubMed Central at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5123227.
Subject(s): Adult
Athletes
Biomarkers/blood
Creatine Kinase/blood
Dietary Supplements
Double-Blind Method
Female
Humans
Inflammation/blood
Interleukin-6/blood
Myalgia/blood
Running/physiology
Sports Nutritional Physiological Phenomena/drug effects
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_pmch_27924138
Host Institution: FSU
Is Part Of: Journal of the International Society of Sports Nutrition.
1550-2783
Issue: vol. 13

Choose the citation style.
Köhne, J. L., Ormsbee, M. J., & McKune, A. J. (2016). The effects of a multi-ingredient supplement on markers of muscle damage and inflammation following downhill running in females. Journal Of The International Society Of Sports Nutrition. Retrieved from http://purl.flvc.org/fsu/fd/FSU_pmch_27924138