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Advances in Zika Virus Research

Title: Advances in Zika Virus Research: Stem Cell Models, Challenges, and Opportunities.
Name(s): Ming, Guo-Li, author
Tang, Hengli, author
Song, Hongjun, author
Type of Resource: text
Genre: Journal Article
Date Issued: 2016-12-01
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: The re-emergence of Zika virus (ZIKV) and its suspected link with various disorders in newborns and adults led the World Health Organization to declare a global health emergency. In response, the stem cell field quickly established platforms for modeling ZIKV exposure using human pluripotent stem cell-derived neural progenitors and brain organoids, fetal tissues, and animal models. These efforts provided significant insight into cellular targets, pathogenesis, and underlying biological mechanisms of ZIKV infection as well as platforms for drug testing. Here we review the remarkable progress in stem cell-based ZIKV research and discuss current challenges and future opportunities.
Identifier: FSU_pmch_27912090 (IID), 10.1016/j.stem.2016.11.014 (DOI), PMC5218815 (PMCID), 27912090 (RID), 27912090 (EID), S1934-5909(16)30415-5 (PII)
Keywords: SpinΩ, Zika, IPSC, Microcephaly, Neurogenesis, Organoid, Outer radial glia cell, Radial glia cell
Grant Number: R01 HD069184, P01 NS097206, R35 NS097370, RM1 HG008935, R01 AG024984, R37 NS047344, U19 MH106434, R21 AI111250, R21 NS095348, R21 MH110160, R21 AI119530, R01 AI079150, R01 NS048271, R01 NS047344, R21 HD086820, R01 MH105128
Publication Note: This NIH-funded author manuscript originally appeared in PubMed Central at
Subject(s): Animals
Models, Biological
Nervous System/pathology
Nervous System/virology
Stem Cell Research
Stem Cells/metabolism
Zika Virus/physiology
Zika Virus Infection/epidemiology
Zika Virus Infection/genetics
Zika Virus Infection/pathology
Zika Virus Infection/virology
Persistent Link to This Record:
Host Institution: FSU
Is Part Of: Cell stem cell.
Issue: iss. 6, vol. 19

Choose the citation style.
Ming, G. -L., Tang, H., & Song, H. (2016). Advances in Zika Virus Research: Stem Cell Models, Challenges, and Opportunities. Cell Stem Cell. Retrieved from