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Acute Sleep Deprivation Blocks Short- and Long-Term Operant Memory in .

Title: Acute Sleep Deprivation Blocks Short- and Long-Term Operant Memory in .
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Name(s): Krishnan, Harini C, author
Gandour, Catherine E, author
Ramos, Joshua L, author
Wrinkle, Mariah C, author
Sanchez-Pacheco, Joseph J, author
Lyons, Lisa C, author
Type of Resource: text
Genre: Journal Article
Text
Date Issued: 2016-12-01
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: Insufficient sleep in individuals appears increasingly common due to the demands of modern work schedules and technology use. Consequently, there is a growing need to understand the interactions between sleep deprivation and memory. The current study determined the effects of acute sleep deprivation on short and long-term associative memory using the marine mollusk , a relatively simple model system well known for studies of learning and memory. were sleep deprived for 9 hours using context changes and tactile stimulation either prior to or after training for the operant learning paradigm, learning that food is inedible (LFI). The effects of sleep deprivation on short-term (STM) and long-term memory (LTM) were assessed. Acute sleep deprivation prior to LFI training impaired the induction of STM and LTM with persistent effects lasting at least 24 h. Sleep deprivation immediately after training blocked the consolidation of LTM. However, sleep deprivation following the period of molecular consolidation did not affect memory recall. Memory impairments were independent of handling-induced stress, as daytime handled control animals demonstrated no memory deficits. Additional training immediately after sleep deprivation failed to rescue the induction of memory, but additional training alleviated the persistent impairment in memory induction when training occurred 24 h following sleep deprivation. Acute sleep deprivation inhibited the induction and consolidation, but not the recall of memory. These behavioral studies establish as an effective model system for studying the interactions between sleep and memory formation.
Identifier: FSU_pmch_27748243 (IID), 10.5665/sleep.6320 (DOI), PMC5103805 (PMCID), 27748243 (RID), 27748243 (EID), sp-00313-16 (PII)
Keywords: Aplysia, Learning and memory, Sleep deprivation
Grant Number: R21 NS088835
Publication Note: This NIH-funded author manuscript originally appeared in PubMed Central at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5103805.
Subject(s): Animals
Aplysia/physiology
Association Learning/physiology
Conditioning, Operant/physiology
Memory, Long-Term/physiology
Memory, Short-Term/physiology
Sleep Deprivation/physiopathology
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_pmch_27748243
Host Institution: FSU
Is Part Of: Sleep.
1550-9109
Issue: iss. 12, vol. 39

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Krishnan, H. C., Gandour, C. E., Ramos, J. L., Wrinkle, M. C., Sanchez-Pacheco, J. J., & Lyons, L. C. (2016). Acute Sleep Deprivation Blocks Short- and Long-Term Operant Memory in . Sleep. Retrieved from http://purl.flvc.org/fsu/fd/FSU_pmch_27748243