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Evidence of a prominent genetic basis for associations between psychoneurometric traits and common mental disorders.

Title: Evidence of a prominent genetic basis for associations between psychoneurometric traits and common mental disorders.
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Name(s): Venables, Noah C, author
Hicks, Brian M, author
Yancey, James R, author
Kramer, Mark D, author
Nelson, Lindsay D, author
Strickland, Casey M, author
Krueger, Robert F, author
Iacono, William G, author
Patrick, Christopher J, author
Type of Resource: text
Genre: Journal Article
Text
Date Issued: 2017-05-01
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: Threat sensitivity (THT) and weak inhibitory control (or disinhibition; DIS) are trait constructs that relate to multiple types of psychopathology and can be assessed psychoneurometrically (i.e., using self-report and physiological indicators combined). However, to establish that psychoneurometric assessments of THT and DIS index biologically-based liabilities, it is important to clarify the etiologic bases of these variables and their associations with clinical problems. The current work addressed this important issue using data from a sample of identical and fraternal adult twins (N=454). THT was quantified using a scale measure and three physiological indicators of emotional reactivity to visual aversive stimuli. DIS was operationalized using scores on two scale measures combined with two brain indicators from cognitive processing tasks. THT and DIS operationalized in these ways both showed appreciable heritability (0.45, 0.68), and genetic variance in these traits accounted for most of their phenotypic associations with fear, distress, and substance use disorder symptoms. Our findings suggest that, as indices of basic dispositional liabilities for multiple forms of psychopathology with direct links to neurophysiology, psychoneurometric assessments of THT and DIS represent novel and important targets for biologically-oriented research on psychopathology.
Identifier: FSU_pmch_27671504 (IID), 10.1016/j.ijpsycho.2016.09.011 (DOI), PMC5364073 (PMCID), 27671504 (RID), 27671504 (EID), S0167-8760(16)30704-8 (PII)
Keywords: Disinhibition, Externalizing, Fear, Inhibitory control, Internalizing, Mental disorders, Psychopathology, Threat sensitivity
Grant Number: P50 MH072850, RC1 MH089727
Publication Note: This NIH-funded author manuscript originally appeared in PubMed Central at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5364073.
Subject(s): Electroencephalography
Electromyography
Fear/psychology
Female
Humans
Inhibition (Psychology)
Male
Mental Disorders/genetics
Mental Disorders/psychology
Neuropsychological Tests
Phenotype
Photic Stimulation
Psychometrics
Regression Analysis
Self Report
Twins, Dizygotic
Twins, Monozygotic
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_pmch_27671504
Owner Institution: FSU
Is Part Of: International journal of psychophysiology : official journal of the International Organization of Psychophysiology.
1872-7697
Issue: vol. 115

Choose the citation style.
Venables, N. C., Hicks, B. M., Yancey, J. R., Kramer, M. D., Nelson, L. D., Strickland, C. M., … Patrick, C. J. (2017). Evidence of a prominent genetic basis for associations between psychoneurometric traits and common mental disorders. International Journal Of Psychophysiology : Official Journal Of The International Organization Of Psychophysiology. Retrieved from http://purl.flvc.org/fsu/fd/FSU_pmch_27671504