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role of ΔfosB in the medial preoptic area

Title: The role of ΔfosB in the medial preoptic area: Differential effects of mating and cocaine history.
Name(s): McHenry, Jenna A, author
Robison, Christopher L, author
Bell, Genevieve A, author
Vialou, Vincent V, author
Bolaños-Guzmán, Carlos A, author
Nestler, Eric J, author
Hull, Elaine M, author
Type of Resource: text
Genre: Journal Article
Date Issued: 2016-10-01
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: The transcription factor deltaFosB (ΔFosB) is induced in the nucleus accumbens (NAc) by repeated exposure to drugs of abuse and natural rewards. Less is known about its role in other brain areas. Here, we compared the effects of mating versus cocaine history on induction of ΔFosB in the medial preoptic area (MPOA), an integral site for reproductive behavior, and in the NAc. ΔFosB immunoreactivity (ir) was increased in the MPOA of previously naïve and experienced male rats that mated the day before euthanasia, compared to unmated controls and experienced males with recent mating abstinence. Western immunoblots confirmed that the 35-37-kDa isoform of ΔFosB was increased more in recently mated males. Conversely, previous plus recent cocaine did not increase ΔFosB-ir in the MPOA, despite an increase in the NAc. Next, a viral vector expressing ΔFosB, its dominant negative antagonist ΔJunD, or green fluorescent protein (GFP) control, were microinjected bilaterally into the MPOA. ΔFosB overexpression impaired copulation and promoted female-directed aggression, compared to ΔJunD and control males. These data suggest that ΔFosB in the mPOA is expressed in an experience-dependent manner and affects systems that coordinate mating and aggression. (PsycINFO Database Record
Identifier: FSU_pmch_27657309 (IID), 10.1037/bne0000160 (DOI), PMC5201202 (PMCID), 27657309 (RID), 27657309 (EID), 2016-45747-001 (PII)
Grant Number: R01 DA007359, R01 MH040826, P01 DA008227, R01 DA026854, R37 DA007359, P50 MH096890
Publication Note: This NIH-funded author manuscript originally appeared in PubMed Central at
Subject(s): Animals
Copulation/drug effects
Nucleus Accumbens/drug effects
Preoptic Area/metabolism
Proto-Oncogene Proteins c-fos/metabolism
Rats, Long-Evans
Sexual Behavior, Animal/drug effects
Persistent Link to This Record:
Owner Institution: FSU
Is Part Of: Behavioral neuroscience.
Issue: iss. 5, vol. 130

Choose the citation style.
McHenry, J. A., Robison, C. L., Bell, G. A., Vialou, V. V., Bolaños-Guzmán, C. A., Nestler, E. J., & Hull, E. M. (2016). The role of ΔfosB in the medial preoptic area: Differential effects of mating and cocaine history. Behavioral Neuroscience. Retrieved from