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Prostaglandin levels, vaginal innervation, and cyst innervation as peripheral contributors to endometriosis-associated vaginal hyperalgesia in rodents.

Title: Prostaglandin levels, vaginal innervation, and cyst innervation as peripheral contributors to endometriosis-associated vaginal hyperalgesia in rodents.
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Name(s): McAllister, Stacy L, author
Giourgas, Barbra K, author
Faircloth, Elizabeth K, author
Leishman, Emma, author
Bradshaw, Heather B, author
Gross, Eric R, author
Type of Resource: text
Genre: Journal Article
Text
Date Issued: 2016-12-05
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: Endometriosis is a painful condition characterized by growth of endometrial cysts outside the uterus. Here, we tested the hypothesis that peripheral innervation and prostaglandin levels contribute to endometriosis-associated pain. Female Sprague-Dawley rats (n = 16) were surgically instrumented by transplanting uterine tissue onto mesenteric arteries within the peritoneal cavity to create a model of endometriosis which forms extra-uterine endometrial cysts and vaginal hyperalgesia. Our results describe a significant positive correlation between endometriosis-induced vaginal hyperalgesia and cyst innervation density (sensory, r = 0.70, p = 0.003; sympathetic, r = 0.55, p = 0.03), vaginal canal sympathetic innervation density (r = 0.80, p = 0.003), and peritoneal fluid levels of the prostaglandins PGE2 (r = 0.65, p = 0.01) and PGF2α (r = 0.63, p = 0.02). These results support the involvement of cyst innervation and prostaglandins in endometriosis-associated pain. We also describe how sympathetic innervation density of the vaginal canal is an important predictor of vaginal hyperalgesia.
Identifier: FSU_pmch_27524411 (IID), 10.1016/j.mce.2016.08.017 (DOI), PMC5048574 (PMCID), 27524411 (RID), 27524411 (EID), S0303-7207(16)30311-2 (PII)
Keywords: Cyst, Endometriosis, Innervation, Pelvic pain, Prostaglandin, Vaginal hyperalgesia
Grant Number: R01 DA006668, R01 NS011892, T32 GM089626
Publication Note: This NIH-funded author manuscript originally appeared in PubMed Central at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5048574.
Subject(s): Animals
Ascitic Fluid/metabolism
Calcitonin Gene-Related Peptide/metabolism
Cysts/complications
Cysts/pathology
Endometriosis/complications
Endometriosis/pathology
Female
Hyperalgesia/complications
Hyperalgesia/pathology
Prostaglandins/metabolism
Rats, Sprague-Dawley
Uterus/innervation
Uterus/pathology
Vagina/innervation
Vagina/pathology
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_pmch_27524411
Host Institution: FSU
Is Part Of: Molecular and cellular endocrinology.
1872-8057
Issue: vol. 437

Choose the citation style.
McAllister, S. L., Giourgas, B. K., Faircloth, E. K., Leishman, E., Bradshaw, H. B., & Gross, E. R. (2016). Prostaglandin levels, vaginal innervation, and cyst innervation as peripheral contributors to endometriosis-associated vaginal hyperalgesia in rodents. Molecular And Cellular Endocrinology. Retrieved from http://purl.flvc.org/fsu/fd/FSU_pmch_27524411