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Marijuana use and viral suppression in persons receiving medical care for HIV-infection.

Title: Marijuana use and viral suppression in persons receiving medical care for HIV-infection.
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Name(s): Okafor, Chukwuemeka N, author
Zhou, Zhi, author
Burrell, Larry E, author
Kelso, Natalie E, author
Whitehead, Nicole E, author
Harman, Jeffery S, author
Cook, Christa L, author
Cook, Robert L, author
Type of Resource: text
Genre: Journal Article
Text
Date Issued: 2017-01-01
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: Marijuana use is common among persons living with HIV (PLWH), but studies on its effect on HIV clinical outcomes are limited. We determined the association between marijuana use and HIV viral suppression among PLWH. Data came from five repeated cross-sections (2009-2013) of the Florida Medical Monitoring Project, a population-based sample of PLWH in Florida. Data were obtained via interview and medical record abstraction (MRA). Weighted logistic regression models were used to determine the association between marijuana use (past 12 months) and durable viral suppression (HIV-1 RNA value of ≤ 200 copies/milliliter in all measurements within the past 12 months). Of the 1,902 PLWH receiving antiretroviral therapy, completed an interview, and had a linked MRA, 20% reported marijuana use (13% less than daily and 7% daily use) and 73% achieved durable viral suppression. In multivariable analysis, marijuana use was not significantly associated with durable viral suppression in daily [Adjusted Odds Ratio (AOR): 0.87, 95% confidence interval (CI): 0.58, 1.33] or in less than daily [AOR: 0.83, 95% CI: 0.51, 1.37] users as compared to non-users when adjusting for sociodemographic factors, time since HIV diagnosis, depressive symptoms, alcohol, cigarette and other substance use. In this sample of PLWH receiving medical care in Florida, there was no statistically significant association between marijuana use and viral suppression. However, as the limits of the confidence intervals include effects that may be considered to be clinically important, there is a need for additional evidence from other samples and settings that include more marijuana users.
Identifier: FSU_pmch_27398989 (IID), 10.1080/00952990.2016.1191505 (DOI), PMC5226929 (PMCID), 27398989 (RID), 27398989 (EID)
Keywords: HIV, Marijuana, Persons living with HIV (PLWH), Viral suppression
Grant Number: F31 AA024064, F31 DA039810, K23 DA039769, U24 AA022002
Publication Note: This NIH-funded author manuscript originally appeared in PubMed Central at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5226929.
Subject(s): Adolescent
Adult
Anti-Retroviral Agents/therapeutic use
Databases, Factual/statistics & numerical data
Female
HIV Infections/drug therapy
HIV Infections/virology
Humans
Male
Marijuana Smoking/blood
Middle Aged
Viral Load/drug effects
Young Adult
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_pmch_27398989
Host Institution: FSU
Is Part Of: The American journal of drug and alcohol abuse.
1097-9891
Issue: iss. 1, vol. 43

Choose the citation style.
Okafor, C. N., Zhou, Z., Burrell, L. E., Kelso, N. E., Whitehead, N. E., Harman, J. S., … Cook, R. L. (2017). Marijuana use and viral suppression in persons receiving medical care for HIV-infection. The American Journal Of Drug And Alcohol Abuse. Retrieved from http://purl.flvc.org/fsu/fd/FSU_pmch_27398989