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Cocaine-induced neurodevelopmental deficits and underlying mechanisms.

Title: Cocaine-induced neurodevelopmental deficits and underlying mechanisms.
Name(s): Martin, Melissa M, author
Graham, Devon L, author
McCarthy, Deirdre M, author
Bhide, Pradeep G, author
Stanwood, Gregg D, author
Type of Resource: text
Genre: Journal Article
Date Issued: 2016-06-01
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: Exposure to drugs early in life has complex and long-lasting implications for brain structure and function. This review summarizes work to date on the immediate and long-term effects of prenatal exposure to cocaine. In utero cocaine exposure produces disruptions in brain monoamines, particularly dopamine, during sensitive periods of brain development, and leads to permanent changes in specific brain circuits, molecules, and behavior. Here, we integrate clinical studies and significance with mechanistic preclinical studies, to define our current knowledge base and identify gaps for future investigation. Birth Defects Research (Part C) 108:147-173, 2016. © 2016 Wiley Periodicals, Inc.
Identifier: FSU_pmch_27345015 (IID), 10.1002/bdrc.21132 (DOI), PMC5538582 (PMCID), 27345015 (RID), 27345015 (EID)
Keywords: Brain, Dopamine, In utero, Prenatal, Psychostimulant
Grant Number: R01 MH086629, R21 DA035588
Publication Note: This NIH-funded author manuscript originally appeared in PubMed Central at
Subject(s): Animals
Brain/drug effects
Cocaine/adverse effects
Neurodevelopmental Disorders/chemically induced
Prenatal Exposure Delayed Effects/chemically induced
Persistent Link to This Record:
Host Institution: FSU
Is Part Of: Birth defects research. Part C, Embryo today : reviews.
Issue: iss. 2, vol. 108

Choose the citation style.
Martin, M. M., Graham, D. L., McCarthy, D. M., Bhide, P. G., & Stanwood, G. D. (2016). Cocaine-induced neurodevelopmental deficits and underlying mechanisms. Birth Defects Research. Part C, Embryo Today : Reviews. Retrieved from