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Toward 20 T magnetic resonance for human brain studies

Title: Toward 20 T magnetic resonance for human brain studies: opportunities for discovery and neuroscience rationale.
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Name(s): Budinger, Thomas F, author
Bird, Mark D, author
Frydman, Lucio, author
Long, Joanna R, author
Mareci, Thomas H, author
Rooney, William D, author
Rosen, Bruce, author
Schenck, John F, author
Schepkin, Victor D, author
Sherry, A Dean, author
Sodickson, Daniel K, author
Springer, Charles S, author
Thulborn, Keith R, author
Uğurbil, Kamil, author
Wald, Lawrence L, author
Type of Resource: text
Genre: Journal Article
Text
Date Issued: 2016-06-01
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: An initiative to design and build magnetic resonance imaging (MRI) and spectroscopy (MRS) instruments at 14 T and beyond to 20 T has been underway since 2012. This initiative has been supported by 22 interested participants from the USA and Europe, of which 15 are authors of this review. Advances in high temperature superconductor materials, advances in cryocooling engineering, prospects for non-persistent mode stable magnets, and experiences gained from large-bore, high-field magnet engineering for the nuclear fusion endeavors support the feasibility of a human brain MRI and MRS system with 1 ppm homogeneity over at least a 16-cm diameter volume and a bore size of 68 cm. Twelve neuroscience opportunities are presented as well as an analysis of the biophysical and physiological effects to be investigated before exposing human subjects to the high fields of 14 T and beyond.
Identifier: FSU_pmch_27194154 (IID), 10.1007/s10334-016-0561-4 (DOI), PMC5538368 (PMCID), 27194154 (RID), 27194154 (EID), 10.1007/s10334-016-0561-4 (PII)
Keywords: Diffusion tensor imaging, High temperature superconductors, Human brain chemistry, Magnetic field physiologic effects, Magnetic resonance imaging, Parallel transmit and receive strategies, Ultrahigh magnetic fields
Grant Number: P41 EB017183
Publication Note: This NIH-funded author manuscript originally appeared in PubMed Central at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538368.
Subject(s): Anisotropy
Axons/pathology
Brain/diagnostic imaging
Brain/pathology
Brain Mapping/methods
Computer Simulation
Energy Metabolism
Glucose/analysis
Hot Temperature
Humans
Magnetic Resonance Imaging
Motion
Neurons/pathology
Permeability
Reproducibility of Results
Sodium-Potassium-Exchanging ATPase/chemistry
Spectrophotometry
Whole Body Imaging
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_pmch_27194154
Owner Institution: FSU
Is Part Of: Magma (New York, N.Y.).
1352-8661
Issue: iss. 3, vol. 29

Choose the citation style.
Budinger, T. F., Bird, M. D., Frydman, L., Long, J. R., Mareci, T. H., Rooney, W. D., … Wald, L. L. (2016). Toward 20 T magnetic resonance for human brain studies: opportunities for discovery and neuroscience rationale. Magma (New York, N.y.). Retrieved from http://purl.flvc.org/fsu/fd/FSU_pmch_27194154