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Neurochemical Mediation of Affiliation and Aggression Associated With Pair-Bonding.

Title: Neurochemical Mediation of Affiliation and Aggression Associated With Pair-Bonding.
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Name(s): Gobrogge, Kyle L, author
Jia, Xixi, author
Liu, Yan, author
Wang, Zuoxin, author
Type of Resource: text
Genre: Journal Article
Text
Date Issued: 2017-02-01
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: The neuropeptides vasopressin and corticotropin-releasing factor facilitate, while serotonin inhibits, aggression. How the brain is wired to coordinate interactions between these functionally opposed neurotransmitters to control behavioral states is poorly understood. Pair-bonded male prairie voles (Microtus ochrogaster) were infused with a retrograde tracer, Fluoro-Gold, and tested for affiliation and aggression toward a female partner or novel female subject. Subsequent immunocytochemical experiments examined neuronal activation using Fos and neurochemical/neuroreceptor profiles on brain areas involved in these social behaviors. Finally, a series of behavioral pharmacologic and real-time in vivo brain microdialysis experiments were performed on male prairie voles displaying affiliation or aggression. We localized a subpopulation of excitatory vasopressin neurons in the anterior hypothalamus that may gate corticotropin-releasing factor output from the amygdala to the anterior hypothalamus and then the lateral septum to modulate aggression associated with mate guarding. Conversely, we identified a subset of inhibitory serotonergic projection neurons in the dorsal raphe that project to the anterior hypothalamus and may mediate the spatiotemporal release of neuropeptides and their interactions in modulating aggression and affiliation. Together, this study establishes the medial extended amygdala as a major neural substrate regulating the switch between positive and negative affective states, wherein several neurochemicals converge and interact to coordinate divergent social behaviors.
Identifier: FSU_pmch_27129413 (IID), 10.1016/j.biopsych.2016.02.013 (DOI), PMC4992658 (PMCID), 27129413 (RID), 27129413 (EID), S0006-3223(16)00100-1 (PII)
Keywords: Anterior hypothalamus, Corticotropin-releasing factor, Dopamine, Medial amygdala, Serotonin, Vasopressin
Grant Number: F31 MH079600, F32 GM096591
Publication Note: This NIH-funded author manuscript originally appeared in PubMed Central at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4992658.
Subject(s): Aggression/physiology
Amygdala/metabolism
Amygdala/physiology
Animals
Arvicolinae
Brain/metabolism
Brain/physiology
Corticotropin-Releasing Hormone/metabolism
Corticotropin-Releasing Hormone/physiology
Dorsal Raphe Nucleus/metabolism
Dorsal Raphe Nucleus/physiology
Female
Hypothalamus/metabolism
Hypothalamus/physiology
Male
Neural Pathways/metabolism
Neural Pathways/physiology
Neurons/metabolism
Neurons/physiology
Neuropeptides/metabolism
Proto-Oncogene Proteins c-fos/metabolism
Receptor, Serotonin, 5-HT1A/physiology
Septal Nuclei/metabolism
Septal Nuclei/physiology
Serotonergic Neurons/metabolism
Serotonergic Neurons/physiology
Serotonin/metabolism
Serotonin/physiology
Social Behavior
Vasopressins/metabolism
Vasopressins/physiology
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_pmch_27129413
Host Institution: FSU
Is Part Of: Biological psychiatry.
1873-2402
Issue: iss. 3, vol. 81

Choose the citation style.
Gobrogge, K. L., Jia, X., Liu, Y., & Wang, Z. (2017). Neurochemical Mediation of Affiliation and Aggression Associated With Pair-Bonding. Biological Psychiatry. Retrieved from http://purl.flvc.org/fsu/fd/FSU_pmch_27129413