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Replication timing and transcriptional control

Title: Replication timing and transcriptional control: beyond cause and effect-part III.
Name(s): Rivera-Mulia, Juan Carlos, author
Gilbert, David M, author
Type of Resource: text
Genre: Journal Article
Date Issued: 2016-06-01
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: DNA replication is essential for faithful transmission of genetic information and is intimately tied to chromosome structure and function. Genome duplication occurs in a defined temporal order known as the replication-timing (RT) program, which is regulated during the cell cycle and development in discrete units referred to as replication domains (RDs). RDs correspond to topologically-associating domains (TADs) and are spatio-temporally compartmentalized in the nucleus. While improvements in experimental tools have begun to reveal glimpses of causality, they have also unveiled complex context-dependent relationships that challenge long recognized correlations of RT to chromatin organization and gene regulation. In particular, RDs/TADs that switch RT during development march to the beat of a different drummer.
Identifier: FSU_pmch_27115331 (IID), 10.1016/ (DOI), PMC4887323 (PMCID), 27115331 (RID), 27115331 (EID), S0955-0674(16)30072-2 (PII)
Grant Number: P01 GM085354, R01 GM083337
Publication Note: This NIH-funded author manuscript originally appeared in PubMed Central at
Subject(s): Animals
Cell Cycle
Cell Nucleus/genetics
DNA Replication
DNA Replication Timing
Gene Expression Regulation
Transcription, Genetic
Persistent Link to This Record:
Owner Institution: FSU
Is Part Of: Current opinion in cell biology.
Issue: vol. 40

Choose the citation style.
Rivera-Mulia, J. C., & Gilbert, D. M. (2016). Replication timing and transcriptional control: beyond cause and effect-part III. Current Opinion In Cell Biology. Retrieved from