You are here

Mediation analysis of relationships between chronic inflammation and quality of life in older adults.

Title: Mediation analysis of relationships between chronic inflammation and quality of life in older adults.
Name(s): Nowakowski, Alexandra C H, author
Graves, Katelyn Y, author
Sumerau, J E, author
Type of Resource: text
Genre: Journal Article
Date Issued: 2016-03-22
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: This article summarizes exploratory analyses of relationships between chronic inflammation, its physical consequences, and quality of life (QoL). It summarizes key findings from preliminary analyses, and contextualizes these results with extant sociomedical literature to recommend directions for future research. Cross-sectional data from the National Social Life, Health, and Aging Project (NSHAP) were used to explore these relationships. Inflammation was assessed via the biomarker C-reactive protein (CRP). We examined associations between CRP levels and two different domains of QoL: happiness with life in general and happiness with intimate relationships. We used ordinal logistic regression with companion OLS models and Sobel-Goodman tests to assess potential mediation, and also conducted a variety of sensitivity analyses. Findings suggest that mediation pathways for the overall association between chronic inflammation and QoL may differ markedly across particular outcome constructs. Specifically, it shows mediation potential for the clinical sequelae of chronic inflammation in frameworks using happiness as an outcome measure, but not in those using relationship satisfaction. Disability appears to mediate the effect of inflammation by 27 %; chronic pain appears to exert a similar mediation effect of 21 %. Pain and disability linked to chronic inflammation appear to play a small but significant mediating role in the overall reduction in QoL observed among older adults with biomarker evidence of chronic inflammation. We note that these patterns are best framed as dynamic elements of a complex causal fabric, rather than powerful determinants that override other factors contributing to QoL. Hypotheses for further exploration using longitudinal data from the NSHAP are thus offered, pending availability of Wave III data in future years.
Identifier: FSU_pmch_27001461 (IID), 10.1186/s12955-016-0452-4 (DOI), PMC4802844 (PMCID), 27001461 (RID), 27001461 (EID), 10.1186/s12955-016-0452-4 (PII)
Keywords: Elaboration modeling, Inflammation, Logistic regression, NSHAP, Quality of life
Publication Note: This NIH-funded author manuscript originally appeared in PubMed Central at
Subject(s): Aged
Aged, 80 and over
Chronic Pain/psychology
Cross-Sectional Studies
Middle Aged
Quality of Life/psychology
United States
Persistent Link to This Record:
Owner Institution: FSU
Is Part Of: Health and quality of life outcomes.
Issue: vol. 14

Choose the citation style.
Nowakowski, A. C. H., Graves, K. Y., & Sumerau, J. E. (2016). Mediation analysis of relationships between chronic inflammation and quality of life in older adults. Health And Quality Of Life Outcomes. Retrieved from