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Wnt-YAP interactions in the neural fate of human pluripotent stem cells and the implications for neural organoid formation.

Title: Wnt-YAP interactions in the neural fate of human pluripotent stem cells and the implications for neural organoid formation.
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Name(s): Bejoy, Julie, author
Song, Liqing, author
Li, Yan, author
Type of Resource: text
Genre: Journal Article
Text
Date Issued: 2016-01-02
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: Human pluripotent stem cells (hPSCs) have shown the ability to self-organize into different types of neural organoids (e.g., whole brain organoids, cortical spheroids, midbrain organoids etc.) recently. The extrinsic and intrinsic signaling elicited by Wnt pathway, Hippo/Yes-associated protein (YAP) pathway, and extracellular microenvironment plays a critical role in brain tissue morphogenesis. This article highlights recent advances in neural tissue patterning from hPSCs, in particular the role of Wnt pathway and YAP activity in this process. Understanding the Wnt-YAP interactions should provide us the guidance to predict and modulate brain-like tissue structure through the regulation of extracellular microenvironment of hPSCs.
Identifier: FSU_pmch_26901039 (IID), 10.1080/15476278.2016.1140290 (DOI), PMC4882124 (PMCID), 26901039 (RID), 26901039 (EID)
Keywords: Wnt, YAP, Neural organoid, Pluripotent stem cell, Three-dimensional
Publication Note: This NIH-funded author manuscript originally appeared in PubMed Central at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4882124.
Subject(s): Adaptor Proteins, Signal Transducing/metabolism
Humans
Neurogenesis/physiology
Organoids/metabolism
Organoids/physiology
Phosphoproteins/metabolism
Pluripotent Stem Cells/cytology
Pluripotent Stem Cells/metabolism
Pluripotent Stem Cells/physiology
Wnt Proteins/metabolism
Wnt Signaling Pathway/physiology
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_pmch_26901039
Owner Institution: FSU
Is Part Of: Organogenesis.
1555-8592
Issue: iss. 1, vol. 12

Choose the citation style.
Bejoy, J., Song, L., & Li, Y. (2016). Wnt-YAP interactions in the neural fate of human pluripotent stem cells and the implications for neural organoid formation. Organogenesis. Retrieved from http://purl.flvc.org/fsu/fd/FSU_pmch_26901039