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sensitivity of fast muscle contractile function to the major components of the sarcomere Ca(2+)-cycling system.

Title: The sensitivity of fast muscle contractile function to the major components of the sarcomere Ca(2+)-cycling system.
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Name(s): Golding, C, author
Kelly, K, author
Kinsey, S T, author
Locke, B R, author
Type of Resource: text
Genre: Journal Article
Text
Date Issued: 2016-04-01
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: A reaction-diffusion model of a muscle sarcomere was developed to evaluate the sensitivity of force characteristics to diffusion and Ca(2+)-cycling components. The model compared well to experimental force measurements. Diffusion led to Ca(2+) gradients that enhanced maximal force and accelerated relaxation compared to when diffusion was infinitely fast. However, a modest increase in sarcomere length or radius led to a decrease in maximal force. Lowering the Ca(2+) release rate caused a lower maximal force, but increasing the rate led to only modest gains in maximal force while incurring much greater ATP costs associated with reuptake. Greater parvalbumin binding rates decreased maximal force but enhanced relaxation, and this effect was magnified when Ca(2+) uptake rates were lowered as may occur during fatigue. These results show a physiological set of parameters that lead to a functional sarcomere of known dimensions and contractile function, and the effects of parameter variation on muscle function.
Identifier: FSU_pmch_26774860 (IID), 10.1016/j.bpc.2016.01.001 (DOI), PMC5003095 (PMCID), 26774860 (RID), 26774860 (EID), S0301-4622(15)30090-9 (PII)
Keywords: Calcium, Contraction, Diffusion, Sarcomere, Sarcoplasmic reticulum, Skeletal muscle
Grant Number: R15 DK106688
Publication Note: This NIH-funded author manuscript originally appeared in PubMed Central at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5003095.
Subject(s): Animals
Bass
Calcium/metabolism
Diffusion
Muscle Contraction
Parvalbumins/metabolism
Sarcomeres/metabolism
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_pmch_26774860
Owner Institution: FSU
Is Part Of: Biophysical chemistry.
1873-4200
Issue: vol. 211

Choose the citation style.
Golding, C., Kelly, K., Kinsey, S. T., & Locke, B. R. (2016). The sensitivity of fast muscle contractile function to the major components of the sarcomere Ca(2+)-cycling system. Biophysical Chemistry. Retrieved from http://purl.flvc.org/fsu/fd/FSU_pmch_26774860