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Ca2+ Effects on ATP Production and Consumption Have Regulatory Roles on Oscillatory Islet Activity.

Title: Ca2+ Effects on ATP Production and Consumption Have Regulatory Roles on Oscillatory Islet Activity.
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Name(s): McKenna, Joseph P, author
Ha, Joon, author
Merrins, Matthew J, author
Satin, Leslie S, author
Sherman, Arthur, author
Bertram, Richard, author
Type of Resource: text
Genre: Journal Article
Text
Date Issued: 2016-02-02
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: Pancreatic islets respond to elevated blood glucose by secreting pulses of insulin that parallel oscillations in β-cell metabolism, intracellular Ca(2+) concentration, and bursting electrical activity. The mechanisms that maintain an oscillatory response are not fully understood, yet several models have been proposed. Only some can account for experiments supporting that metabolism is intrinsically oscillatory in β-cells. The dual oscillator model (DOM) implicates glycolysis as the source of oscillatory metabolism. In the companion article, we use recently developed biosensors to confirm that glycolysis is oscillatory and further elucidate the coordination of metabolic and electrical signals in the insulin secretory pathway. In this report, we modify the DOM by incorporating an established link between metabolism and intracellular Ca(2+) to reconcile model predictions with experimental observations from the companion article. With modification, we maintain the distinguishing feature of the DOM, oscillatory glycolysis, but introduce the ability of Ca(2+) influx to reshape glycolytic oscillations by promoting glycolytic efflux. We use the modified model to explain measurements from the companion article and from previously published experiments with islets.
Identifier: FSU_pmch_26840737 (IID), 10.1016/j.bpj.2015.11.3526 (DOI), PMC4744176 (PMCID), 26840737 (RID), 26840737 (EID), S0006-3495(15)04814-6 (PII)
Grant Number: K01-DK101683, R01 DK046409, K01 DK101683, , P30 DK020572, R01-DK46409
Publication Note: This NIH-funded author manuscript originally appeared in PubMed Central at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4744176.
Subject(s): Action Potentials
Adenosine Triphosphate/metabolism
Animals
Calcium/metabolism
Calcium Signaling
Energy Metabolism
Glycolysis
Humans
Insulin-Secreting Cells/metabolism
Insulin-Secreting Cells/physiology
Models, Theoretical
Periodicity
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_pmch_26840737
Owner Institution: FSU
Is Part Of: Biophysical journal.
1542-0086
Issue: iss. 3, vol. 110

Choose the citation style.
McKenna, J. P., Ha, J., Merrins, M. J., Satin, L. S., Sherman, A., & Bertram, R. (2016). Ca2+ Effects on ATP Production and Consumption Have Regulatory Roles on Oscillatory Islet Activity. Biophysical Journal. Retrieved from http://purl.flvc.org/fsu/fd/FSU_pmch_26840737