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Tests for equivalence of two survival functions

Title: Tests for equivalence of two survival functions: Alternative to the tests under proportional hazards.
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Name(s): Martinez, Elvis E, author
Sinha, Debajyoti, author
Wang, Wenting, author
Lipsitz, Stuart R, author
Chappell, Richard J, author
Type of Resource: text
Genre: Journal Article
Text
Date Issued: 2017-02-01
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: For either the equivalence trial or the non-inferiority trial with survivor outcomes from two treatment groups, the most popular testing procedure is the extension (e.g., Wellek, A log-rank test for equivalence of two survivor functions, Biometrics, 1993; 49: 877-881) of log-rank based test under proportional hazards model. We show that the actual type I error rate for the popular procedure of Wellek is higher than the intended nominal rate when survival responses from two treatment arms satisfy the proportional odds survival model. When the true model is proportional odds survival model, we show that the hypothesis of equivalence of two survival functions can be formulated as a statistical hypothesis involving only the survival odds ratio parameter. We further show that our new equivalence test, formulation, and related procedures are applicable even in the presence of additional covariates beyond treatment arms, and the associated equivalence test procedures have correct type I error rates under the proportional hazards model as well as the proportional odds survival model. These results show that use of our test will be a safer statistical practice for equivalence trials of survival responses than the commonly used log-rank based tests.
Identifier: FSU_pmch_24925887 (IID), 10.1177/0962280214539282 (DOI), PMC5557049 (PMCID), 24925887 (RID), 24925887 (EID), 0962280214539282 (PII)
Keywords: Cox’s model, Clinical importance, Critical region, Proportional odds survival model
Grant Number: R01 CA069222
Publication Note: This NIH-funded author manuscript originally appeared in PubMed Central at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5557049.
Subject(s): Child
Equivalence Trials as Topic
Humans
Lymphoma, B-Cell/drug therapy
Odds Ratio
Proportional Hazards Models
Research Design
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_pmch_24925887
Owner Institution: FSU
Is Part Of: Statistical methods in medical research.
1477-0334
Issue: iss. 1, vol. 26

Choose the citation style.
Martinez, E. E., Sinha, D., Wang, W., Lipsitz, S. R., & Chappell, R. J. (2017). Tests for equivalence of two survival functions: Alternative to the tests under proportional hazards. Statistical Methods In Medical Research. Retrieved from http://purl.flvc.org/fsu/fd/FSU_pmch_24925887