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Transmissible Tumors

Title: Transmissible Tumors: Breaking the Cancer Paradigm.
Name(s): Ostrander, Elaine A, author
Davis, Brian W, author
Ostrander, Gary K, author
Type of Resource: text
Genre: Journal Article
Date Issued: 2016-01-01
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: Transmissible tumors are those that have transcended the bounds of their incipient hosts by evolving the ability to infect another individual through direct transfer of cancer cells, thus becoming parasitic cancer clones. Coitus, biting, and scratching are transfer mechanisms for the two primary species studied, the domestic dog (Canis lupus familiaris) and the Tasmanian devil (Sarcophilus harrisii). Canine transmissible venereal tumors (CTVT) are likely thousands of years old, and have successfully travelled from host to host around the world, while the Tasmanian devil facial tumor disease (DFTD) is much younger and geographically localized. The dog tumor is not necessarily lethal, while the devil tumor has driven the population to near extinction. Transmissible tumors are uniform in that they have complex immunologic profiles, which allow them to escape immune detection by their hosts, sometimes for long periods of time. In this review, we explore how transmissible tumors in CTVT, DFTD, and as well as the soft-shell clam and Syrian hamster, can advance studies of tumor biology.
Identifier: FSU_pmch_26686413 (IID), 10.1016/j.tig.2015.10.001 (DOI), PMC4698198 (PMCID), 26686413 (RID), 26686413 (EID), S0168-9525(15)00187-0 (PII)
Keywords: Cancer, Canine, Clonal, Devil, Infectious, Transmissible
Grant Number: ZIA HG200325-06
Publication Note: This NIH-funded author manuscript originally appeared in PubMed Central at
Subject(s): Animals
Biological Evolution
Dog Diseases/transmission
Facial Neoplasms/veterinary
Genetic Variation
Venereal Tumors, Veterinary
Persistent Link to This Record:
Owner Institution: FSU
Is Part Of: Trends in genetics : TIG.
Issue: iss. 1, vol. 32

Choose the citation style.
Ostrander, E. A., Davis, B. W., & Ostrander, G. K. (2016). Transmissible Tumors: Breaking the Cancer Paradigm. Trends In Genetics : Tig. Retrieved from