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Synergistic Pleiotropy Overrides the Costs of Complexity in Viral Adaptation.

Title: Synergistic Pleiotropy Overrides the Costs of Complexity in Viral Adaptation.
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Name(s): McGee, Lindsey W, author
Sackman, Andrew M, author
Morrison, Anneliese J, author
Pierce, Jessica, author
Anisman, Jeremy, author
Rokyta, Darin R, author
Type of Resource: text
Genre: Journal Article
Text
Date Issued: 2016-01-01
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: Adaptive evolution progresses as a series of steps toward a multidimensional phenotypic optimum, and organismal or environmental complexity determines the number of phenotypic dimensions, or traits, under selection. Populations evolving in complex environments may experience costs of complexity such that improvement in one or more traits is impeded by selection on others. We compared the fitness effects of the first fixed mutations for populations of single-stranded DNA bacteriophage evolving under simple selection for growth rate to those of populations evolving under more complex selection for growth rate as well as capsid stability. We detected a cost of complexity manifested as a smaller growth rate improvement for mutations fixed under complex conditions. We found that, despite imposing a cost for growth rate improvement, strong complex selection resulted in the greatest overall fitness improvement, even for single mutations. Under weaker secondary selective pressures, tradeoffs between growth rate and stability were pervasive, but strong selection on the secondary trait resulted largely in mutations beneficial to both traits. Strength of selection therefore determined the nature of pleiotropy governing observed trait evolution, and strong positive selection forced populations to find mutations that improved multiple traits, thereby overriding costs incurred as a result of a more complex selective environment. The costs of complexity, however, remained substantial when considering the effects on a single trait in the context of selection on multiple traits.
Identifier: FSU_pmch_26564159 (IID), 10.1534/genetics.115.181628 (DOI), PMC4701092 (PMCID), 26564159 (RID), 26564159 (EID), genetics.115.181628 (PII)
Keywords: Bacteriophage, Complexity, Pleiotropy, Strong selection
Grant Number: R01 GM099723, T32 GM007759
Publication Note: This NIH-funded author manuscript originally appeared in PubMed Central at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4701092.
Subject(s): Adaptation, Biological
Biological Evolution
Directed Molecular Evolution
Genetic Pleiotropy
Mutation
Myoviridae/genetics
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_pmch_26564159
Owner Institution: FSU
Is Part Of: Genetics.
1943-2631
Issue: iss. 1, vol. 202

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McGee, L. W., Sackman, A. M., Morrison, A. J., Pierce, J., Anisman, J., & Rokyta, D. R. (2016). Synergistic Pleiotropy Overrides the Costs of Complexity in Viral Adaptation. Genetics. Retrieved from http://purl.flvc.org/fsu/fd/FSU_pmch_26564159