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Vicarious social defeat stress

Title: Vicarious social defeat stress: Bridging the gap between physical and emotional stress.
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Name(s): Sial, Omar K, author
Warren, Brandon L, author
Alcantara, Lyonna F, author
Parise, Eric M, author
Bolaños-Guzmán, Carlos A, author
Type of Resource: text
Genre: Journal Article
Text
Date Issued: 2016-01-30
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: Animal models capable of differentiating the neurobiological intricacies between physical and emotional stress are scarce. Current models rely primarily on physical stressors (e.g., chronic unpredictable or mild stress, social defeat, learned helplessness), and neglect the impact of psychological stress alone. This is surprising given extensive evidence that a traumatic event needs not be directly experienced to produce enduring perturbations on an individual's health and psychological well-being. Post-traumatic stress disorder (PTSD), a highly debilitating neuropsychiatric disorder characterized by intense fear of trauma-related stimuli, often occurs in individuals that have only witnessed a traumatic event. By modifying the chronic social defeat stress (CSDS) paradigm to include a witness component (witnessing the social defeat of another mouse), we demonstrate a novel behavioral paradigm capable of inducing a robust behavioral syndrome reminiscent of PTSD in emotionally stressed adult mice. We describe the vicarious social defeat stress (VSDS) model that is capable of inducing a host of behavioral deficits that include social avoidance and other depressive- and anxiety-like phenotypes in adult male mice. VSDS exposure induces weight loss and spike in serum corticosterone (CORT) levels. A month after stress, these mice retain the social avoidant phenotype and have an increased CORT response when exposed to subsequent stress. The VSDS is a novel paradigm capable of inducing emotional stress by isolating physical stress/confrontation in mice. The VSDS model can be used to study the short- and long-term neurobiological consequences of exposure to emotional stress in mice.
Identifier: FSU_pmch_26545443 (IID), 10.1016/j.jneumeth.2015.10.012 (DOI), PMC4691556 (PMCID), 26545443 (RID), 26545443 (EID), S0165-0270(15)00392-1 (PII)
Keywords: Depression, Emotional stress, PTSD, Social defeat, Witness stress
Grant Number: F31 MH103939, R01DA026854, F31MH103939, R01 DA026854, R21 DA022351
Publication Note: This NIH-funded author manuscript originally appeared in PubMed Central at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691556.
Subject(s): Animals
Behavior, Animal/physiology
Corticosterone/blood
Disease Models, Animal
Fear/physiology
Male
Mice
Social Behavior
Social Dominance
Stress Disorders, Post-Traumatic/blood
Stress Disorders, Post-Traumatic/physiopathology
Stress, Physiological/physiology
Stress, Psychological/blood
Stress, Psychological/physiopathology
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_pmch_26545443
Owner Institution: FSU
Is Part Of: Journal of neuroscience methods.
1872-678X
Issue: vol. 258

Choose the citation style.
Sial, O. K., Warren, B. L., Alcantara, L. F., Parise, E. M., & Bolaños-Guzmán, C. A. (2016). Vicarious social defeat stress: Bridging the gap between physical and emotional stress. Journal Of Neuroscience Methods. Retrieved from http://purl.flvc.org/fsu/fd/FSU_pmch_26545443