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Disturbance Of Gut Satiety Peptide In Purging Disorder

Title: Disturbance Of Gut Satiety Peptide In Purging Disorder.
Name(s): Keel, Pamela K., author
Eckel, Lisa A., author
Hildebrandt, Britny A., author
Haedt-Matt, Alissa A., author
Appelbaum, Jonathan, author
Jimerson, David C., author
Type of Resource: text
Genre: Journal Article
Journal Article
Date Issued: 2018-01
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: ObjectiveLittle is known about biological factors that contribute to purging after normal amounts of foodthe central feature of purging disorder (PD). This study comes from a series of nested studies examining ingestive behaviors in bulimic syndromes and specifically evaluated the satiety peptide YY (PYY) and the hunger peptide ghrelin in women with PD (n=25), bulimia nervosa-purging (BNp) (n=26), and controls (n=26). Based on distinct subjective responses to a fixed meal in PD (Keel, Wolfe, Liddle, DeYoung, & Jimerson, ), we tested whether postprandial PYY response was significantly greater and ghrelin levels significantly lower in women with PD compared to controls and women with BNp. MethodParticipants completed structured clinical interviews, self-report questionnaires, and laboratory assessments of gut peptide and subjective responses to a fixed meal. ResultsWomen with PD demonstrated a significantly greater postprandial PYY response compared to women with BNp and controls, who did not differ significantly. PD women also endorsed significantly greater gastrointestinal distress, and PYY predicted gastrointestinal intestinal distress. Ghrelin levels were significantly greater in PD and BNp compared to controls, but did not differ significantly between eating disorders. Women with BNp endorsed significantly greater postprandial hunger, and ghrelin predicted hunger. DiscussionPD is associated with a unique disturbance in PYY response. Findings contribute to growing evidence of physiological distinctions between PD and BNp. Future research should examine whether these distinctions account for differences in clinical presentation as this could inform the development of specific interventions for patients with PD.
Identifier: FSU_libsubv1_wos_000418270800007 (IID), 10.1002/eat.22806 (DOI)
Keywords: questionnaire, adolescents, classification, eating-disorders, physiology, bulimia-nervosa, cholecystokinin, food-intake, bulimia nervosa, ghrelin, gut peptides, metoclopramide, purging disorder, test meal, yy
Publication Note: The publisher's version of record is available at
Persistent Link to This Record:
Host Institution: FSU
Is Part Of: International Journal of Eating Disorders.
Issue: iss. 1, vol. 51

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Keel, P. K., Eckel, L. A., Hildebrandt, B. A., Haedt-Matt, A. A., Appelbaum, J., & Jimerson, D. C. (2018). Disturbance Of Gut Satiety Peptide In Purging Disorder. International Journal Of Eating Disorders. Retrieved from