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Attention And Working Memory Deficits In A Perinatal Nicotine Exposure Mouse Model

Title: Attention And Working Memory Deficits In A Perinatal Nicotine Exposure Mouse Model.
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Name(s): Zhang, Lin, author
Spencer, Thomas J., author
Biederman, Joseph, author
Bhide, Pradeep G., author
Type of Resource: text
Genre: Journal Article
Text
Journal Article
Date Issued: 2018-05-24
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: Background Cigarette smoking by pregnant women is associated with a significant increase in the risk for cognitive disorders in their children. Preclinical models confirm this risk by showing that exposure of the developing brain to nicotine produces adverse behavioral outcomes. Here we describe behavioral phenotypes resulting from perinatal nicotine exposure in a mouse model, and discuss our findings in the context of findings from previously published studies using preclinical models of developmental nicotine exposure. Methodology/Principal findings Female C57BI/6 mice received drinking water containing nicotine (100pg/ml) + saccharin (2%) starting 3 weeks prior to breeding and continuing throughout pregnancy, and until 3 weeks postpartum. Over the same period, female mice in two control groups received drinking water containing saccharin (2%) or plain drinking water. Offspring from each group were weaned at 3-weeks of age and subjected to behavioral analyses at 3 months of age. We examined spontaneous locomotor activity, anxiety-like behavior, spatial working memory, object based attention, recognition memory and impulsive-like behavior. We found significant deficits in attention and working memory only in male mice, and no significant changes in the other behavioral phenotypes in male or female mice. Exposure to saccharin alone did not produce significant changes in either sex. Conclusion/Significance The perinatal nicotine exposure produced significant deficits in attention and working memory in a sex-dependent manner in that the male but not female offspring displayed these behaviors. These behavioral phenotypes are associated with attention deficit hyperactivity disorder (ADHD) and have been reported in other studies that used pre-or perinatal nicotine exposure. Therefore, we suggest that preclinical models of developmental nicotine exposure could be useful tools for modeling ADHD and related disorders.
Identifier: FSU_libsubv1_wos_000433084300123 (IID), 10.1371/journal.pone.0198064 (DOI)
Keywords: different time-windows, sex-differences, dna methylation, acetylcholine-receptor expression, brain-development, cigarette-smoke, deficit/hyperactivity disorder, environmental tobacco-smoke, in-utero, origin allelic expression
Publication Note: The publisher’s version of record is available at https://doi.org/10.1371/journal.pone.0198064
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_libsubv1_wos_000433084300123
Owner Institution: FSU
Is Part Of: Plos One.
1932-6203
Issue: iss. 5, vol. 13

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Zhang, L., Spencer, T. J., Biederman, J., & Bhide, P. G. (2018). Attention And Working Memory Deficits In A Perinatal Nicotine Exposure Mouse Model. Plos One. Retrieved from http://purl.flvc.org/fsu/fd/FSU_libsubv1_wos_000433084300123