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Emetine Inhibits Zika And Ebola Virus Infections Through Two Molecular Mechanisms

Title: Emetine Inhibits Zika And Ebola Virus Infections Through Two Molecular Mechanisms: Inhibiting Viral Replication And Decreasing Viral Entry.
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Name(s): Yang, Shu, author
Xu, Miao, author
Lee, Emily M., author
Gorshkov, Kirill, author
Shiryaev, Sergey A., author
He, Shihua, author
Sun, Wei, author
Cheng, Yu-Shan, author
Hu, Xin, author
Tharappel, Anil Mathew, author
Lu, Billy, author
Pinto, Antonella, author
Farhy, Chen, author
Huang, Chun-Teng, author
Zhang, Zirui, author
Zhu, Wenjun, author
Wu, Yuying, author
Zhou, Yi, author
Song, Guang, author
Zhu, Heng, author
Shamim, Khalida, author
Martinez-Romero, Carles, author
Garcia-Sastre, Adolfo, author
Preston, Richard A., author
Jayaweera, Dushyantha T., author
Huang, Ruili, author
Huang, Wenwei, author
Xia, Menghang, author
Simeonov, Anton, author
Ming, Guoli, author
Qiu, Xiangguo, author
Terskikh, Alexey, author
Tang, Hengli, author
Song, Hongjun, author
Zheng, Wei, author
Type of Resource: text
Genre: Journal Article
Text
Journal Article
Date Issued: 2018-06-05
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: The re-emergence of Zika virus (ZIKV) and Ebola virus (EBOV) poses serious and continued threats to the global public health. Effective therapeutics for these maladies is an unmet need. Here, we show that emetine, an anti-protozoal agent, potently inhibits ZIKV and EBOV infection with a low nanomolar half maximal inhibitory concentration (IC50) in vitro and potent activity in vivo. Two mechanisms of action for emetine are identified: the inhibition of ZIKV NS5 polymerase activity and disruption of lysosomal function. Emetine also inhibits EBOV entry. Cephaeline, a desmethyl analog of emetine, which may be better tolerated in patients than emetine, exhibits a similar efficacy against both ZIKV and EBOV infections. Hence, emetine and cephaeline offer pharmaceutical therapies against both ZIKV and EBOV infection.
Identifier: FSU_libsubv1_wos_000434231100001 (IID), 10.1038/s41421-018-0034-1 (DOI)
Keywords: system, identification, models, rna, assay, dengue, cardiotoxicity, niemann-pick c1, repurposing screen
Publication Note: The publisher’s version of record is available at https://doi.org/10.1038/s41421-018-0034-1
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_libsubv1_wos_000434231100001
Host Institution: FSU
Is Part Of: Cell Discovery.
2056-5968
Issue: vol. 4

Choose the citation style.
Yang, S., Xu, M., Lee, E. M., Gorshkov, K., Shiryaev, S. A., He, S., … Zheng, W. (2018). Emetine Inhibits Zika And Ebola Virus Infections Through Two Molecular Mechanisms: Inhibiting Viral Replication And Decreasing Viral Entry. Cell Discovery. Retrieved from http://purl.flvc.org/fsu/fd/FSU_libsubv1_wos_000434231100001