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Diverse Intrinsic Properties Shape Functional Phenotype Of Low-frequency Neurons In The Auditory Brainstem

Title: Diverse Intrinsic Properties Shape Functional Phenotype Of Low-frequency Neurons In The Auditory Brainstem.
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Name(s): Hong, Hui, author
Wang, Xiaoyu, author
Lu, Ting, author
Zorio, Diego A. R., author
Wang, Yuan, author
Sanchez, Jason Tait, author
Type of Resource: text
Genre: Journal Article
Text
Journal Article
Date Issued: 2018-06-26
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: In the auditory system, tonotopy is the spatial arrangement of where sounds of different frequencies are processed. Defined by the organization of neurons and their inputs, tonotopy emphasizes distinctions in neuronal structure and function across topographic gradients and is a common feature shared among vertebrates. In this study we characterized action potential firing patterns and ion channel properties from neurons located in the extremely low-frequency region of the chicken nucleus magnocellularis (NM), an auditory brainstem structure. We found that NM neurons responsible for encoding the lowest sound frequencies (termed NMc neurons) have enhanced excitability and fired bursts of action potentials to sinusoidal inputs <= 10 Hz; a distinct firing pattern compared to higher-frequency neurons. This response property was due to lower amounts of voltage dependent potassium (K-v) conductances, unique combination of K-v subunits and specialized sodium (Na-v) channel properties. Particularly, NMc neurons had significantly lower K(v)1 and K(v)3 currents, but higher K(v)2current. NMc neurons also showed larger and faster transient Nav current (I-NaT) with different voltage dependence of inactivation from higher-frequency neurons. In contrast, significantly smaller resurgent sodium current (I-NaR) was present in NMc with kinetics and voltage dependence that differed from higher-frequency neurons. Immunohistochemistry showed expression of Na(v)1.6 channel subtypes across the tonotopic axis. However, various immunoreactive patterns were observed between regions, likely underlying some tonotopic differences in I-N(aT) and I-NaR. Finally, using pharmacology and computational modeling, we concluded that K(v)3, K(v)2 channels and I-NaR work synergistically to regulate burst firing in NMc.
Identifier: FSU_libsubv1_wos_000436338700001 (IID), 10.3389/fncel.2018.00175 (DOI)
Keywords: potassium channels, cochlear nucleus, potassium channel, cerebellar purkinje neurons, nucleus magnocellularis, open-channel block, ionic currents, action potentials, auditory brainstem, avian nucleus magnocellularis, coincidence detection, firing patterns, mesencephalic trigeminal neurons, resurgent sodium current, resurgent sodium current, sodium channels, tonotopic map
Publication Note: The publisher’s version of record is available at https://doi.org/10.3389/fncel.2018.00175
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_libsubv1_wos_000436338700001
Owner Institution: FSU
Is Part Of: Frontiers in Cellular Neuroscience.
1662-5102
Issue: vol. 12

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Hong, H., Wang, X., Lu, T., Zorio, D. A. R., Wang, Y., & Sanchez, J. T. (2018). Diverse Intrinsic Properties Shape Functional Phenotype Of Low-frequency Neurons In The Auditory Brainstem. Frontiers In Cellular Neuroscience. Retrieved from http://purl.flvc.org/fsu/fd/FSU_libsubv1_wos_000436338700001