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Modular Access To Functionalized 5-8-5 Fused Ring Systems Via A Photoinduced Cycloisomerization Reaction

Title: Modular Access To Functionalized 5-8-5 Fused Ring Systems Via A Photoinduced Cycloisomerization Reaction.
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Name(s): Salvati, Anna E., author
Law, James A., author
Liriano, Josue, author
Frederich, James H., author
Type of Resource: text
Genre: Journal Article
Text
Journal Article
Date Issued: 2018-06-28
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: A 5-8-5 carbocyclic ring system forms the core of over 30 distinct natural products. Several members of this family have gained attention for their diverse activity in cell culture. In these cases, biological function is mediated by the arrangement of substituents around a conserved 5-8-5 nucleus. Despite the potential applications of this privileged substructure in medicinal chemistry, modular strategies for its assembly are underdeveloped. Herein, we describe a cycloisomerization reaction that forms the 5-8-5 framework directly. This strategy uniquely allows access to gram quantities of this valuable scaffold in four steps.
Identifier: FSU_libsubv1_wos_000436027800011 (IID), 10.1039/c8sc00999f (DOI)
Keywords: complex, (+)-ophiobolin, 4+4 cycloaddition, diterpenes, pyran-2-ones
Publication Note: The publisher’s version of record is available at https://doi.org/10.1039/c8sc00999f
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_libsubv1_wos_000436027800011
Owner Institution: FSU
Is Part Of: Chemical Science.
2041-6520
Issue: iss. 24, vol. 9

Choose the citation style.
Salvati, A. E., Law, J. A., Liriano, J., & Frederich, J. H. (2018). Modular Access To Functionalized 5-8-5 Fused Ring Systems Via A Photoinduced Cycloisomerization Reaction. Chemical Science. Retrieved from http://purl.flvc.org/fsu/fd/FSU_libsubv1_wos_000436027800011