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Troponin Through The Looking-glass

Title: Troponin Through The Looking-glass: Emerging Roles Beyond Regulation Of Striated Muscle Contraction.
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Name(s): Johnston, Jamie R., author
Chase, P. Bryant, author
Pinto, Jose Renato, author
Type of Resource: text
Genre: Journal Article
Text
Journal Article
Date Issued: 2018-01-02
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: Troponin is a heterotrimeric Ca2+-binding protein that has a well-established role in regulating striated muscle contraction. However, mounting evidence points to novel cellular functions of troponin, with profound implications in cancer, cardiomyopathy pathogenesis and skeletal muscle aging. Here, we highlight the non-canonical roles and aberrant expression patterns of troponin beyond the sarcomeric milieu. Utilizing bioinformatics tools and online databases, we also provide pathway, subcellular localization, and protein-protein/DNA interaction analyses that support a role for troponin in multiple subcellular compartments. This emerging knowledge challenges the conventional view of troponin as a sarcomere-specific protein exclusively involved in muscle contraction and may transform the way we think about sarcomeric proteins, particularly in the context of human disease and aging.
Identifier: FSU_libsubv1_wos_000419615500116 (IID), 10.18632/oncotarget.22879 (DOI)
Keywords: gene-expression, troponin, nucleus, cancer, skeletal-muscle, tumor-growth, acute myocardial-infarction, cardiomyopathy, human cancer-cells, human cardiac troponin, hypertrophic cardiomyopathy mutations, mesenchymal stem-cells, nuclear-myosin-i, polymerase-i transcription, striated muscle
Publication Note: The publisher's version of record is available at https://doi.org/10.18632/oncotarget.22879
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_libsubv1_wos_000419615500116
Owner Institution: FSU
Is Part Of: Oncotarget.
1949-2553
Issue: iss. 1, vol. 9

Choose the citation style.
Johnston, J. R., Chase, P. B., & Pinto, J. R. (2018). Troponin Through The Looking-glass: Emerging Roles Beyond Regulation Of Striated Muscle Contraction. Oncotarget. Retrieved from http://purl.flvc.org/fsu/fd/FSU_libsubv1_wos_000419615500116