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Analytical separations with polyelectrolyte layers, molecular micelles, or zwitterionic polymers

Title: Analytical separations with polyelectrolyte layers, molecular micelles, or zwitterionic polymers.
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Name(s): Schlenoff, Joseph B., inventor
Warner, Isiah M., inventor
Kapnissi, Constantina P., inventor
Type of Resource: text
Genre: Utility
Text
Date Created: 2002-10-30
Date Issued: 2008-01-01
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: Polymeric surfactants (molecular micelles) are disclosed for use in open tubular capillary electrochromatography or in high performance liquid chromatography. For example, fused silica capillaries are coated with thin films of charged polymers in a polyelectrolyte multilayer (PEM). A PEM coating may be formed in situ by alternate rinses with positive and negative polyelectrolytes. At least the innermost of the negatively charged polymer layers is a molecular micelle. Prototype embodiments have successfully separated seven benzodiazepines from one another. The run-to-run, day-to-day, week-to-week and capillary-to-capillary reproducibilities were very good, with relative standard deviation values less than 0.01. The PEM-coated capillary was very robust over at least 200 runs. Stability against high and low pH values was also observed. Using chiral polymerized micelles, chiral separations may be achieved, as was demonstrated with a separation of the enantiomers of 1,1′-binaphthyl-2,2′-dihydrogenphosphate. Alternatively, layers for use in this invention may be formed from zwitterionic polymers in lieu of separate cationic and anionic layers. Zwitterionic polymer layers may be used either with or without molecular micelles.
Identifier: FSU_uspto_7314550 (IID), 7314550 (patent number), 915739 (inventor key), 10/283471 (app id), 600b83161da1122888348587dc18798c (assignee id)
Cited by US patents: 2
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_uspto_7314550
Use and Reproduction: Copyright not evaluated
Owner Institution: FSU

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Analytical separations with polyelectrolyte layers, molecular micelles, or zwitterionic polymers. (2008). Analytical separations with polyelectrolyte layers, molecular micelles, or zwitterionic polymers. Retrieved from http://purl.flvc.org/fsu/fd/FSU_uspto_7314550