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Method for preparation of taxol using an oxazinone

Title: Method for preparation of taxol using an oxazinone.
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Name(s): Holton, Robert A., inventor
Type of Resource: text
Genre: Utility
Text
Date Created: 1989-11-14
Date Issued: 1991-05-14
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: Process for the preparation of a taxol intermediate comprising contacting an alcohol with an oxazinone having the formula: ##STR1## wherein R.sub.1 is aryl, substituted aryl, alkyl, alkenyl, or alkynyl; R.sub.2 is hydrogen, ethoxyethyl, 2,2,2-trichloroethoxymethyl or other hydroxyl protecting group; and R.sub.3 is aryl, substituted aryl, alkyl, alkenyl, or alkynyl; the contacting of said alcohol and oxazinone being carried out in the presence of a sufficient amount of an activating agent under effective conditions to cause the oxazinone to react with the alcohol to form a .beta.-amido ester which is suitable for use as an intermediate in the synthesis of taxol.
Identifier: FSU_uspto_5015744 (IID), 5015744 (patent number), 711524 (inventor key), 07/436235 (app id), 600b83161da1122888348587dc18798c (assignee id)
Cited by US patents: 179
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_uspto_5015744
Use and Reproduction: Copyright not evaluated
Owner Institution: FSU

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Method for preparation of taxol using an oxazinone. (1991). Method for preparation of taxol using an oxazinone. Retrieved from http://purl.flvc.org/fsu/fd/FSU_uspto_5015744