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High Resolution MR Imaging of Amyloid Deposition in a Genetic Model of Familial Alzheimer's Disease

Title: High Resolution MR Imaging of Amyloid Deposition in a Genetic Model of Familial Alzheimer's Disease.
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Name(s): Palin, Tara Nicole, author
Type of Resource: text
Genre: Text
Bachelor Thesis
Date Issued: 2018-04-25
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: Alzheimer’s disease (AD) is the most common form of dementia characterized by a gradual loss in memory, reasoning and orientation. Currently clinical diagnosis of AD required documentation of progressive decline in memory by means of longitudinal clinical examinations and neuropsychologic tests. Unfortunately, due to clinical criteria, these tests are less than 70% accurate when diagnosing AD. Traditionally diagnosed postmortem by the observation of amyloid-beta (A) deposits in the brain. Cleavage of the amyloid precursor protein (APP) by - and -secretase results in plaque deposition, however mutations in presenilin1 (PS1) is known to affect this function, accelerating the rate at which the plaques are generated. A subgroup of cases has been termed familial AD (FAD) since they have been attributed to a genetic defect mapped to chromosome 21 by genetic linkage analysis. Despite the early onset seen in FAD patients, the pathology and symptoms have been found to be similar to that of the non-inherited form. This project utilizes the 5xFAD APP/PS1 double transgenic mouse model since it is known to have an aggressive and rapid plaque deposition, starting at around 2-months. Since this model does not show to have any significant tau pathology, it is representative of an amyloid-predominant model. In order to observe changes in plaque density and overall brain volume, 3D gradient-recalled echo fast low angle shot (GRE FLASH), more specifically gradient echo Fourier imaging tomography (GEFI-TOMO) were acquired. Scans acquired with a spatial resolution of 50-m were acquired at two different magnetic field strengths of 11.75-T (500-MHz) and 21.1-T (900-MHz) at two different echo times (TE). Scans acquired with a spatial resolution of 25-m were only acquired at 21.1-T. All scans were acquired at two different echo times (TE) of 7.5 and 15-ms. It was found that the optimal scan parameters when trying to best compromise when trying to optimize the SNR and spatial resolution for plaque visualization. Due to the presumed presence of iron in the plaques, susceptibility-weighted images (SWI) were acquired in order to try and exploit susceptibility differences in tissue. T2* values were estimated and showed a decrease when comparing 1- to 6-month samples due to iron causing changes in plaque voxel contrast. This decrease is assumed to be caused by the increased presence of plaques, however the TE times observed were not able to quantify these values by means of T2* mapping. More echo times would need to be evaluated in order to better fit the data to an exponential curve.
Identifier: FSU_libsubv1_scholarship_submission_1524840305_d08907cb (IID)
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_libsubv1_scholarship_submission_1524840305_d08907cb
Owner Institution: FSU
Is Part Of: High Resolution MR Imaging of Amyloid Deposition in a Genetic Model of Familial Alzheimer's Disease.

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Palin, T. N. (2018). High Resolution MR Imaging of Amyloid Deposition in a Genetic Model of Familial Alzheimer's Disease. High Resolution Mr Imaging Of Amyloid Deposition In A Genetic Model Of Familial Alzheimer's Disease. Retrieved from http://purl.flvc.org/fsu/fd/FSU_libsubv1_scholarship_submission_1524840305_d08907cb