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Modeling HCV Interactions with p53 in Hepatocytes

Title: Modeling HCV Interactions with p53 in Hepatocytes: Implications for Carcinogenesis.
Name(s): Poole, Maria Isabella, author
Type of Resource: text
Genre: Text
Bachelor Thesis
Date Issued: 2017-12-07
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Summary: Infection with Hepatitis C virus (HCV) has reached epidemic proportions; it is one of the least tested for, but often one of the most dangerous silent killers among American men. Individuals with chronic HCV infection, without access to treatment, are at high risk for developing Hepatocellular Carcinoma (HCC), a liver cancer that is rapidly fatal after diagnosis. The unnerving part about this cancer is that because it can escape immune defenses, patients can be living with this virus for more than 30 years without any symptoms; the subsequent development of liver cancer goes unnoticed for years. There is strong experimental evidence that shows virus protein can directly interact with the p53 pathway, thereby modulating its action by preventing p53 from mediating cell death and contributing to carcinogenesis. Once p53 is mutated by the virus protein, the infected individual has a higher chance of developing cancer. Unfortunately, the mechanism of interaction between p53 and the virus protein remains to be elucidated. That is why a mathematical model of the virus/cancer progression is needed. By using biochemically-motivated mathematical modeling, we can describe p53 regulation within the cell and its interactions with the HCV virus core protein. The model will also be based on previously published models of p53 regulation; but will include virus core protein-p53-FBP1 interactions, which has not been done before. The goal of this research is to use mathematical modeling to understand the p53 interaction with infected hepatocytes and the eventual development of cancer.
Identifier: FSU_libsubv1_scholarship_submission_1512751301_36ac24ff (IID)
Keywords: HCV, HCC, Hepatitis C virus, hepatocellular carcinoma, liver cancer, p53, hepatocytes, carcinogenesis
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Owner Institution: FSU

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Poole, M. I. (2017). Modeling HCV Interactions with p53 in Hepatocytes: Implications for Carcinogenesis. Retrieved from