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Distinct neural properties in the low frequency region of the chicken cochlear nucleus magnocellularis

Title: Distinct neural properties in the low frequency region of the chicken cochlear nucleus magnocellularis.
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Name(s): Wang, Xiaoyu, author
Hong, Hui, author
Brown, David H., author
Sanchez, Jason T., author
Wang, Yuan, author
Type of Resource: text
Genre: Text
Journal Article
Date Issued: 2017-04-11
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: Topography in the avian cochlear nucleus magnocellularis (NM) is represented as gradually increasing characteristic frequency (CF) along the caudolateral to rostromedial axis. In this study, we characterized the organization and cell biophysics of the caudolateral NM (NMc) in chickens (Gallus gallus domesticus). Examination of cellular and dendritic architecture first revealed that NMc contains small neurons and extensive dendritic processes, in contrast to adendritic, large neurons located more rostromedially. Individual dye-filling study further demonstrated that NMc is divided into two subregions, with NMc2 neurons having larger and more complex dendritic fields than NMc1. Axonal tract tracing studies confirmed that NMc1 and NMc2 neurons receive afferent inputs from the auditory nerve and the superior olivary nucleus, similar to the adendritic NM. However, the auditory axons synapse with NMc neurons via small bouton-like terminals, unlike the large end-bulb synapses on adendritic NM neurons. Immunocytochemistry demonstrated that most NMc2 neurons express cholecystokinin but not calretinin, distinct from NMc1 and adendritic NM neurons that are cholecystokinin-negative and mostly calretinin-positive. Finally, whole-cell current clamp recordings revealed that NMc neurons require significantly lower threshold current for action potential generation than adendritic NM neurons. Moreover, in contrast to adendritic NM neurons that generate a single onset action potential, NMc neurons generate multiple action potentials to suprathreshold sustained depolarization. Taken together, our data indicate that NMc contains multiple neuron types that are structurally, connectively, molecularly, and physiologically different from traditionally defined NM neurons, emphasizing specialized neural properties for processing low frequency sounds.
Identifier: FSU_libsubv1_scholarship_submission_1511841863_674f6e29 (IID), 10.1523/ENEURO.0016-17.2017 (DOI)
Preferred Citation: Wang X, Hong H, Brown DH, Sanchez JT, Wang Y. Distinct Neural Properties in the Low-Frequency Region of the Chicken Cochlear Nucleus Magnocellularis. eNeuro. 2017 Apr 11;4(2). pii: ENEURO.0016-17.2017. doi: 10.1523/ENEURO.0016-17.2017. eCollection 2017 Mar-Apr. PMID: 28413822, PMCID: PMC5388668
Grant Number: DC013074 (YW) and DC013841 (JTS)
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_libsubv1_scholarship_submission_1511841863_674f6e29
Owner Institution: FSU
Is Part Of: eNeuro.
Issue: iss. 2, vol. 4

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Wang, X., Hong, H., Brown, D. H., Sanchez, J. T., & Wang, Y. (2017). Distinct neural properties in the low frequency region of the chicken cochlear nucleus magnocellularis. Eneuro. Retrieved from http://purl.flvc.org/fsu/fd/FSU_libsubv1_scholarship_submission_1511841863_674f6e29