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Sphingolipids in spinal cord injury.

Title: Sphingolipids in spinal cord injury.
Name(s): Jones, Zachary B, author
Ren, Yi, author
Type of Resource: text
Genre: Journal Article
Date Issued: 2016-08-05
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: Spinal cord injury (SCI) is a debilitating condition that affects millions of individuals worldwide. Despite progress over the last few decades, the molecular mechanisms of secondary SCI that continue to occur days and weeks after the original trauma remain poorly understood. As a result, current therapies for SCI are only marginally effective. Sphingolipids, a diverse class of bioactive lipids, have been shown to regulate SCI repair and key secondary injury processes such as apoptosis, ischemia and inflammation. This review will discuss the numerous roles of sphingolipids and highlight the potential of sphingolipid-targeted therapies for SCI.
Identifier: FSU_pmch_27570580 (IID), PMC4981650 (PMCID), 27570580 (RID), 27570580 (EID)
Keywords: S1P, Spinal cord injury, Apoptosis, Ceramide, Inflammation, Sphingolipid metabolism
Grant Number: R01 GM072611, R01 GM100474
Publication Note: This NIH-funded author manuscript originally appeared in PubMed Central at
Persistent Link to This Record:
Owner Institution: FSU
Is Part Of: International journal of physiology, pathophysiology and pharmacology.
Issue: iss. 2, vol. 8

Choose the citation style.
Jones, Z. B., & Ren, Y. (2016). Sphingolipids in spinal cord injury. International Journal Of Physiology, Pathophysiology And Pharmacology. Retrieved from