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Neurons That Underlie Drosophila melanogaster Reproductive Behaviors

Title: Neurons That Underlie Drosophila melanogaster Reproductive Behaviors: Detection of a Large Male-Bias in Gene Expression in fruitless-Expressing Neurons.
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Name(s): Newell, Nicole R, author
New, Felicia N, author
Dalton, Justin E, author
McIntyre, Lauren M, author
Arbeitman, Michelle N, author
Type of Resource: text
Genre: Journal Article
Text
Date Issued: 2016-08-09
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: Male and female reproductive behaviors in Drosophila melanogaster are vastly different, but neurons that express sex-specifically spliced fruitless transcripts (fru P1) underlie these behaviors in both sexes. How this set of neurons can generate such different behaviors between the two sexes is an unresolved question. A particular challenge is that fru P1-expressing neurons comprise only 2-5% of the adult nervous system, and so studies of adult head tissue or whole brain may not reveal crucial differences. Translating Ribosome Affinity Purification (TRAP) identifies the actively translated pool of mRNAs from fru P1-expressing neurons, allowing a sensitive, cell-type-specific assay. We find four times more male-biased than female-biased genes in TRAP mRNAs from fru P1-expressing neurons. This suggests a potential mechanism to generate dimorphism in behavior. The male-biased genes may direct male behaviors by establishing cell fate in a similar context of gene expression observed in females. These results suggest a possible global mechanism for how distinct behaviors can arise from a shared set of neurons.
Identifier: FSU_pmch_27247289 (IID), 10.1534/g3.115.019265 (DOI), PMC4978899 (PMCID), 27247289 (RID), 27247289 (EID), g3.115.019265 (PII)
Keywords: Drosophila, Courtship behaviors, Fruitless, Genetics of sex, Sex differences, Sex hierarchy
Grant Number: R01 GM073039, R01 MH091561
Publication Note: This NIH-funded author manuscript originally appeared in PubMed Central at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4978899.
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_pmch_27247289
Owner Institution: FSU
Is Part Of: G3 (Bethesda, Md.).
2160-1836
Issue: iss. 8, vol. 6

Choose the citation style.
Newell, N. R., New, F. N., Dalton, J. E., McIntyre, L. M., & Arbeitman, M. N. (2016). Neurons That Underlie Drosophila melanogaster Reproductive Behaviors: Detection of a Large Male-Bias in Gene Expression in fruitless-Expressing Neurons. G3 (Bethesda, Md.). Retrieved from http://purl.flvc.org/fsu/fd/FSU_pmch_27247289