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LARP6 Meets Collagen mRNA

Title: LARP6 Meets Collagen mRNA: Specific Regulation of Type I Collagen Expression.
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Name(s): Zhang, Yujie, author
Stefanovic, Branko, author
Type of Resource: text
Genre: Journal Article
Text
Date Issued: 2016-03-22
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: Type I collagen is the most abundant structural protein in all vertebrates, but its constitutive rate of synthesis is low due to long half-life of the protein (60-70 days). However, several hundred fold increased production of type I collagen is often seen in reparative or reactive fibrosis. The mechanism which is responsible for this dramatic upregulation is complex, including multiple levels of regulation. However, posttranscriptional regulation evidently plays a predominant role. Posttranscriptional regulation comprises processing, transport, stabilization and translation of mRNAs and is executed by RNA binding proteins. There are about 800 RNA binding proteins, but only one, La ribonucleoprotein domain family member 6 (LARP6), is specifically involved in type I collagen regulation. In the 5'untranslated region (5'UTR) of mRNAs encoding for type I and type III collagens there is an evolutionally conserved stem-loop (SL) structure; this structure is not found in any other mRNA, including any other collagen mRNA. LARP6 binds to the 5'SL in sequence specific manner to regulate stability of collagen mRNAs and their translatability. Here, we will review current understanding of how is LARP6 involved in posttranscriptional regulation of collagen mRNAs. We will also discuss how other proteins recruited by LARP6, including nonmuscle myosin, vimentin, serine threonine kinase receptor associated protein (STRAP), 25 kD FK506 binding protein (FKBP25) and RNA helicase A (RHA), contribute to this process.
Identifier: FSU_pmch_27011170 (IID), 10.3390/ijms17030419 (DOI), PMC4813270 (PMCID), 27011170 (RID), 27011170 (EID), ijms17030419 (PII)
Keywords: LARP6, Collagen mRNA binding protein, Collagen mRNA translation, Posttranscriptional regulation, Ribonucleoprotein complexes, Type I collagen
Grant Number: R01 DK059466, 5R01DK059466-11
Publication Note: This NIH-funded author manuscript originally appeared in PubMed Central at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4813270.
Subject(s): Animals
Autoantigens/genetics
Autoantigens/metabolism
Collagen Type I/genetics
Collagen Type I/metabolism
Humans
Protein Binding
RNA Processing, Post-Transcriptional
RNA Stability
RNA, Messenger/genetics
RNA, Messenger/metabolism
Ribonucleoproteins/genetics
Ribonucleoproteins/metabolism
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_pmch_27011170
Owner Institution: FSU
Is Part Of: International journal of molecular sciences.
1422-0067
Issue: iss. 3, vol. 17

Choose the citation style.
Zhang, Y., & Stefanovic, B. (2016). LARP6 Meets Collagen mRNA: Specific Regulation of Type I Collagen Expression. International Journal Of Molecular Sciences. Retrieved from http://purl.flvc.org/fsu/fd/FSU_pmch_27011170