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Depressive symptoms, thyroid hormone and autoimmunity in a population-based cohort from Sardinia.

Title: Depressive symptoms, thyroid hormone and autoimmunity in a population-based cohort from Sardinia.
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Name(s): Delitala, Alessandro P, author
Terracciano, Antonio, author
Fiorillo, Edoardo, author
Orrù, Valeria, author
Schlessinger, David, author
Cucca, Francesco, author
Type of Resource: text
Genre: Journal Article
Text
Date Issued: 2016-02-01
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: To evaluate the association between depressive symptoms and thyroid autoimmunity, and the effect of thyroid hormone on the risk of depression. We included 3138 individuals from SardiNIA project, none of whom was taking thyroid medication and antidepressants. Thyrotropin (TSH), free thyroxine (FT4), and antibodies against thyroperoxidase (TPOAb) were measured in all the sample. Depressive symptoms were assessed with Center for Epidemiologic Studies Depression Scale (CES-D). We found no association between TPOAb and depressive symptoms and no linear association between TSH or FT4 levels and depressive symptoms. However, individuals in the lowest and highest FT4 quintiles showed a higher CES-D score compared to individuals in the middle quintile. In addition, participants in the lowest and highest FT4 quintiles had an increased risk of CES-D≥16 with odds ratios of 1.44 (95% CI=1.09-1.89) and 1.33 (95% CI=1.01-1.77), respectively. Cross-sectional design of the study. A U-shaped relation was found between FT4 and depressive symptoms: compared to average FT4 values, both high and low thyroid function was associated with more depressive symptoms. Further studies are necessary to determine the exact cause-effect relation of this association.
Identifier: FSU_pmch_26655116 (IID), 10.1016/j.jad.2015.11.019 (DOI), PMC4715961 (PMCID), 26655116 (RID), 26655116 (EID), S0165-0327(15)30912-5 (PII)
Keywords: Center for Epidemiologic Studies Depression Scale, Depression, Depressive symptoms, Free thyroxine, Thyroid hormone
Grant Number: N01 AG012109
Publication Note: This NIH-funded author manuscript originally appeared in PubMed Central at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4715961.
Subject(s): Adult
Autoantibodies/blood
Autoantigens/immunology
Autoimmunity
Cross-Sectional Studies
Depression/immunology
Female
Humans
Iodide Peroxidase/immunology
Iron-Binding Proteins/immunology
Italy
Male
Middle Aged
Odds Ratio
Risk
Thyroid Function Tests
Thyroid Gland/metabolism
Thyroid Gland/physiopathology
Thyroid Hormones/immunology
Thyrotropin/immunology
Thyroxine/immunology
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_pmch_26655116
Owner Institution: FSU
Is Part Of: Journal of affective disorders.
1573-2517
Issue: vol. 191

Choose the citation style.
Delitala, A. P., Terracciano, A., Fiorillo, E., Orrù, V., Schlessinger, D., & Cucca, F. (2016). Depressive symptoms, thyroid hormone and autoimmunity in a population-based cohort from Sardinia. Journal Of Affective Disorders. Retrieved from http://purl.flvc.org/fsu/fd/FSU_pmch_26655116