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Examination of Dynamic Gene Expression Changes in the Mouse Brain During Pregnancy and the Postpartum Period.

Title: An Examination of Dynamic Gene Expression Changes in the Mouse Brain During Pregnancy and the Postpartum Period.
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Name(s): Ray, Surjyendu, author
Tzeng, Ruei-Ying, author
DiCarlo, Lisa M, author
Bundy, Joseph L, author
Vied, Cynthia, author
Tyson, Gary, author
Nowakowski, Richard, author
Arbeitman, Michelle N, author
Type of Resource: text
Genre: Journal Article
Text
Date Issued: 2015-11-23
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: The developmental transition to motherhood requires gene expression changes that alter the brain to drive the female to perform maternal behaviors. We broadly examined the global transcriptional response in the mouse maternal brain, by examining four brain regions: hypothalamus, hippocampus, neocortex, and cerebellum, in virgin females, two pregnancy time points, and three postpartum time points. We find that overall there are hundreds of differentially expressed genes, but each brain region and time point shows a unique molecular signature, with only 49 genes differentially expressed in all four regions. Interestingly, a set of "early-response genes" is repressed in all brain regions during pregnancy and postpartum stages. Several genes previously implicated in underlying postpartum depression change expression. This study serves as an atlas of gene expression changes in the maternal brain, with the results demonstrating that pregnancy, parturition, and postpartum maternal experience substantially impact diverse brain regions.
Identifier: FSU_pmch_26596646 (IID), 10.1534/g3.115.020982 (DOI), PMC4704721 (PMCID), 26596646 (RID), 26596646 (EID), g3.115.020982 (PII)
Keywords: Genetics of Sex, RNA-seq, Gene expression, Mouse, Parturition, Postpartum, Pregnancy
Publication Note: This NIH-funded author manuscript originally appeared in PubMed Central at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4704721.
Subject(s): Animals
Behavior, Animal
Brain/metabolism
Cluster Analysis
Computational Biology/methods
Depression, Postpartum/genetics
Female
Gene Expression Profiling
Gene Expression Regulation
Gene Ontology
High-Throughput Nucleotide Sequencing
Humans
Male
Mice
Phenotype
Postpartum Period
Pregnancy
Transcriptome
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_pmch_26596646
Owner Institution: FSU
Is Part Of: G3 (Bethesda, Md.).
2160-1836
Issue: iss. 1, vol. 6

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Ray, S., Tzeng, R. -Y., DiCarlo, L. M., Bundy, J. L., Vied, C., Tyson, G., … Arbeitman, M. N. (2015). An Examination of Dynamic Gene Expression Changes in the Mouse Brain During Pregnancy and the Postpartum Period. G3 (Bethesda, Md.). Retrieved from http://purl.flvc.org/fsu/fd/FSU_pmch_26596646