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Fluoxetine exposure during adolescence increases preference for cocaine in adulthood.

Title: Fluoxetine exposure during adolescence increases preference for cocaine in adulthood.
Name(s): Iñiguez, Sergio D, author
Riggs, Lace M, author
Nieto, Steven J, author
Wright, Katherine N, author
Zamora, Norma N, author
Cruz, Bryan, author
Zavala, Arturo R, author
Robison, Alfred J, author
Mazei-Robison, Michelle S, author
Type of Resource: text
Genre: Journal Article
Date Issued: 2015-10-09
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: Currently, there is a high prevalence of antidepressant prescription rates within juvenile populations, yet little is known about the potential long-lasting consequences of such treatments, particularly on subsequent responses to drugs of abuse. To address this issue at the preclinical level, we examined whether adolescent exposure to fluoxetine (FLX), a selective serotonin reuptake inhibitor, results in changes to the sensitivity of the rewarding properties of cocaine in adulthood. Separate groups of male c57bl/6 mice were exposed to FLX (0 or 20 mg/kg) for 15 consecutive days either during adolescence (postnatal days [PD] 35-49) or adulthood (PD 65-79). Twenty-one days after FLX treatment, behavioral responsivity to cocaine (0, 2.5, 5, 10, or 20 mg/kg) conditioned place preference was assessed. Our data shows that mice pretreated with FLX during adolescence, but not during adulthood, display an enhanced dose-dependent preference to the environment paired with cocaine (5 or 10 mg/kg) when compared to age-matched saline pretreated controls. Taken together, our findings suggest that adolescent exposure to FLX increases sensitivity to the rewarding properties of cocaine, later in life.
Identifier: FSU_pmch_26449406 (IID), 10.1038/srep15009 (DOI), PMC4598853 (PMCID), 26449406 (RID), 26449406 (EID), srep15009 (PII)
Grant Number: SC2 GM109811, SC2GM109811
Publication Note: This NIH-funded author manuscript originally appeared in PubMed Central at
Subject(s): Age Factors
Conditioning (Psychology)/drug effects
Conditioning (Psychology)/physiology
Dopamine Uptake Inhibitors/pharmacology
Dose-Response Relationship, Drug
Food Preferences/drug effects
Mice, Inbred C57BL
Serotonin Uptake Inhibitors/pharmacology
Time Factors
Persistent Link to This Record:
Owner Institution: FSU
Is Part Of: Scientific reports.
Issue: vol. 5

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Iñiguez, S. D., Riggs, L. M., Nieto, S. J., Wright, K. N., Zamora, N. N., Cruz, B., … Mazei-Robison, M. S. (2015). Fluoxetine exposure during adolescence increases preference for cocaine in adulthood. Scientific Reports. Retrieved from