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TGF-β Signaling Regulates the Differentiation of Motile Cilia.

Title: TGF-β Signaling Regulates the Differentiation of Motile Cilia.
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Name(s): Tözser, Janos, author
Earwood, Ryan, author
Kato, Akiko, author
Brown, Jacob, author
Tanaka, Koichi, author
Didier, Ruth, author
Megraw, Timothy L, author
Blum, Martin, author
Kato, Yoichi, author
Type of Resource: text
Genre: Journal Article
Text
Date Issued: 2015-05-19
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: The cilium is a small cellular organelle with motility- and/or sensory-related functions that plays a crucial role during developmental and homeostatic processes. Although many molecules or signal transduction pathways that control cilia assembly have been reported, the mechanisms of ciliary length control have remained enigmatic. Here, we report that Smad2-dependent transforming growth factor β (TGF-β) signaling impacts the length of motile cilia at the Xenopus left-right (LR) organizer, the gastrocoel roof plate (GRP), as well as at the neural tube and the epidermis. Blocking TGF-β signaling resulted in the absence of the transition zone protein B9D1/MSKR-1 from cilia in multi-ciliated cells (MCCs) of the epidermis. Interestingly, this TGF-β activity is not mediated by Mcidas, Foxj1, and RFX2, the known major regulators of ciliogenesis. These data indicate that TGF-β signaling is crucial for the function of the transition zone, which in turn may affect the regulation of cilia length.
Identifier: FSU_pmch_25959824 (IID), 10.1016/j.celrep.2015.04.025 (DOI), PMC4439334 (PMCID), 25959824 (RID), 25959824 (EID), S2211-1247(15)00412-X (PII)
Grant Number: R15 GM087641, GM087641
Publication Note: This NIH-funded author manuscript originally appeared in PubMed Central at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4439334.
Subject(s): Animals
Cilia/metabolism
Cilia/ultrastructure
Immunohistochemistry
Microscopy, Confocal
Signal Transduction/physiology
Smad2 Protein/metabolism
Transforming Growth Factor beta/metabolism
Xenopus/embryology
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_pmch_25959824
Owner Institution: FSU
Is Part Of: Cell reports.
2211-1247
Issue: iss. 7, vol. 11

Choose the citation style.
Tözser, J., Earwood, R., Kato, A., Brown, J., Tanaka, K., Didier, R., … Kato, Y. (2015). TGF-β Signaling Regulates the Differentiation of Motile Cilia. Cell Reports. Retrieved from http://purl.flvc.org/fsu/fd/FSU_pmch_25959824