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Light-regulated translational control of circadian behavior by eIF4E phosphorylation.

Title: Light-regulated translational control of circadian behavior by eIF4E phosphorylation.
Name(s): Cao, Ruifeng, author
Gkogkas, Christos G, author
de Zavalia, Nuria, author
Blum, Ian D, author
Yanagiya, Akiko, author
Tsukumo, Yoshinori, author
Xu, Haiyan, author
Lee, Choogon, author
Storch, Kai-Florian, author
Liu, Andrew C, author
Amir, Shimon, author
Sonenberg, Nahum, author
Type of Resource: text
Genre: Journal Article
Date Issued: 2015-06-01
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: The circadian (∼24 h) clock is continuously entrained (reset) by ambient light so that endogenous rhythms are synchronized with daily changes in the environment. Light-induced gene expression is thought to be the molecular mechanism underlying clock entrainment. mRNA translation is a key step of gene expression, but the manner in which clock entrainment is controlled at the level of mRNA translation is not well understood. We found that a light- and circadian clock-regulated MAPK/MNK pathway led to phosphorylation of the cap-binding protein eIF4E in the mouse suprachiasmatic nucleus of the hypothalamus, the locus of the master circadian clock in mammals. Phosphorylation of eIF4E specifically promoted translation of Period 1 (Per1) and Period 2 (Per2) mRNAs and increased the abundance of basal and inducible PER proteins, which facilitated circadian clock resetting and precise timekeeping. Together, these results highlight a critical role for light-regulated translational control in the physiology of the circadian clock.
Identifier: FSU_pmch_25915475 (IID), 10.1038/nn.4010 (DOI), PMC4446158 (PMCID), 25915475 (RID), 25915475 (EID), nn.4010 (PII)
Grant Number: MOP 114994, R01NS054794, , R01 NS054794, R01 GM066157, MOP 13625
Publication Note: This NIH-funded author manuscript originally appeared in PubMed Central at
Subject(s): Animals
Behavior, Animal/physiology
Behavior, Animal/radiation effects
Brain Chemistry/genetics
Brain Chemistry/physiology
Circadian Rhythm/physiology
Circadian Rhythm/radiation effects
Eukaryotic Initiation Factor-4E/physiology
Gene Expression Regulation/radiation effects
MAP Kinase Signaling System/radiation effects
Mice, Inbred C57BL
Period Circadian Proteins/genetics
Period Circadian Proteins/physiology
Suprachiasmatic Nucleus/metabolism
Suprachiasmatic Nucleus/physiology
Persistent Link to This Record:
Owner Institution: FSU
Is Part Of: Nature neuroscience.
Issue: iss. 6, vol. 18

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Cao, R., Gkogkas, C. G., De Zavalia, N., Blum, I. D., Yanagiya, A., Tsukumo, Y., … Sonenberg, N. (2015). Light-regulated translational control of circadian behavior by eIF4E phosphorylation. Nature Neuroscience. Retrieved from