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Exercise training reverses aging-induced impairment of myogenic constriction in skeletal muscle arterioles.

Title: Exercise training reverses aging-induced impairment of myogenic constriction in skeletal muscle arterioles.
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Name(s): Ghosh, Payal, author
Mora Solis, Fredy R, author
Dominguez, James M, author
Spier, Scott A, author
Donato, Anthony J, author
Delp, Michael D, author
Muller-Delp, Judy M, author
Type of Resource: text
Genre: Journal Article
Text
Date Issued: 2015-04-01
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: To investigate whether exercise training can reverse age-related impairment of myogenic vasoconstriction in skeletal muscle arterioles, young (4 mo) and old (22 mo) male Fischer 344 rats were randomly assigned to either sedentary or exercise-trained groups. The roles of the endothelium and Kv1 channels in age- and exercise training-induced adaptations of myogenic responses were assessed through evaluation of pressure-induced constriction in endothelium-intact and denuded soleus muscle arterioles in the presence and absence of the Kv1 channel blocker, correolide. Exercise training enhanced myogenic constriction in arterioles from both old and young rats. In arterioles from old rats, exercise training restored myogenic constriction to a level similar to that of arterioles from young sedentary rats. Removal of the endothelium did not alter myogenic constriction of arterioles from young sedentary rats, but reduced myogenic constriction in arterioles from young exercise-trained rats. In contrast, endothelial removal had no effect on myogenic constriction of arterioles from old exercise-trained rats, but increased myogenic vasoconstriction in old sedentary rats. The effect of Kv1 channel blockade was also dependent on age and training status. In arterioles from young sedentary rats, Kv1 blockade had little effect on myogenic constriction, whereas in old sedentary rats Kv1 blockade increased myogenic constriction. After exercise training, Kv1 channel blockade increased myogenic constriction in arterioles from both young and old rats. Thus exercise training restores myogenic constriction of arterioles from old rats and enhances myogenic constriction from young rats through adaptations of the endothelium and smooth muscle Kv1 channels.
Identifier: FSU_pmch_25634999 (IID), 10.1152/japplphysiol.00277.2014 (DOI), PMC4422370 (PMCID), 25634999 (RID), 25634999 (EID), japplphysiol.00277.2014 (PII)
Keywords: Correolide, Endothelium, Myogenic
Grant Number: R21 AG043952, R01 HL-090937, R01 HL-077224, K02 AG045339, R01 AG040297
Publication Note: This NIH-funded author manuscript originally appeared in PubMed Central at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4422370.
Subject(s): Aging/physiology
Animals
Arterioles/physiology
Blood Flow Velocity/physiology
Male
Muscle, Skeletal/blood supply
Muscle, Skeletal/physiology
Muscle, Smooth/physiology
Physical Conditioning, Animal/methods
Rats
Rats, Inbred F344
Vasoconstriction/physiology
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_pmch_25634999
Owner Institution: FSU
Is Part Of: Journal of applied physiology (Bethesda, Md. : 1985).
1522-1601
Issue: iss. 7, vol. 118

Choose the citation style.
Ghosh, P., Mora Solis, F. R., Dominguez, J. M., Spier, S. A., Donato, A. J., Delp, M. D., & Muller-Delp, J. M. (2015). Exercise training reverses aging-induced impairment of myogenic constriction in skeletal muscle arterioles. Journal Of Applied Physiology (Bethesda, Md. : 1985). Retrieved from http://purl.flvc.org/fsu/fd/FSU_pmch_25634999