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Spaceflight on the Bion-M1 biosatellite alters cerebral artery vasomotor and mechanical properties in mice.

Title: Spaceflight on the Bion-M1 biosatellite alters cerebral artery vasomotor and mechanical properties in mice.
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Name(s): Sofronova, Svetlana I, author
Tarasova, Olga S, author
Gaynullina, Dina, author
Borzykh, Anna A, author
Behnke, Bradley J, author
Stabley, John N, author
McCullough, Danielle J, author
Maraj, Joshua J, author
Hanna, Mina, author
Muller-Delp, Judy M, author
Vinogradova, Olga L, author
Delp, Michael D, author
Type of Resource: text
Genre: Journal Article
Text
Date Issued: 2015-04-01
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: Conditions during spaceflight, such as the loss of the head-to-foot gravity vector, are thought to potentially alter cerebral blood flow and vascular resistance. The purpose of the present study was to determine the effects of long-term spaceflight on the functional, mechanical, and structural properties of cerebral arteries. Male C57BL/6N mice were flown 30 days in a Bion-M1 biosatellite. Basilar arteries isolated from spaceflight (SF) (n = 6), habitat control (HC) (n = 6), and vivarium control (VC) (n = 16) mice were used for in vitro functional and mechanical testing and histological structural analysis. The results demonstrate that vasoconstriction elicited through a voltage-gated Ca(2+) mechanism (30-80 mM KCl) and thromboxane A2 receptors (10(-8) - 3 × 10(-5) M U46619) are lower in cerebral arteries from SF mice. Inhibition of Rho-kinase activity (1 μM Y27632) abolished group differences in U46619-evoked contractions. Endothelium-dependent vasodilation elicited by acetylcholine (10 μM, 2 μM U46619 preconstriction) was virtually absent in cerebral arteries from SF mice. The pressure-diameter relation was lower in arteries from SF mice relative to that in HC mice, which was not related to differences in the extracellular matrix protein elastin or collagen content or the elastin/collagen ratio in the basilar arteries. Diameter, medial wall thickness, and medial cross-sectional area of unpressurized basilar arteries were not different among groups. These results suggest that the microgravity-induced attenuation of both vasoconstrictor and vasodilator properties may limit the range of vascular control of cerebral perfusion or impair the distribution of brain blood flow during periods of stress.
Identifier: FSU_pmch_25593287 (IID), 10.1152/japplphysiol.00976.2014 (DOI), PMC4385880 (PMCID), 25593287 (RID), 25593287 (EID), japplphysiol.00976.2014 (PII)
Keywords: Brain blood flow, Endothelium-dependent vasodilation, Microgravity, Vasoconstriction
Publication Note: This NIH-funded author manuscript originally appeared in PubMed Central at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4385880.
Subject(s): Adaptation, Physiological/physiology
Animals
Blood Flow Velocity/physiology
Calcium/metabolism
Cerebral Arteries/anatomy & histology
Cerebral Arteries/physiology
Cerebrovascular Circulation/physiology
Elastic Modulus/physiology
Endothelium, Vascular/physiology
Male
Mice
Mice, Inbred C57BL
Potassium Channels, Voltage-Gated/physiology
Receptors, Thromboxane A2, Prostaglandin H2/metabolism
Space Flight
Spacecraft
Vascular Stiffness/physiology
Vasoconstriction/physiology
Vasodilation/physiology
Vasomotor System/physiology
Weightlessness Simulation
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_pmch_25593287
Owner Institution: FSU
Is Part Of: Journal of applied physiology (Bethesda, Md. : 1985).
1522-1601
Issue: iss. 7, vol. 118

Choose the citation style.
Sofronova, S. I., Tarasova, O. S., Gaynullina, D., Borzykh, A. A., Behnke, B. J., Stabley, J. N., … Delp, M. D. (2015). Spaceflight on the Bion-M1 biosatellite alters cerebral artery vasomotor and mechanical properties in mice. Journal Of Applied Physiology (Bethesda, Md. : 1985). Retrieved from http://purl.flvc.org/fsu/fd/FSU_pmch_25593287