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Epigenetic mechanisms underlying the role of brain-derived neurotrophic factor in depression and response to antidepressants.

Title: Epigenetic mechanisms underlying the role of brain-derived neurotrophic factor in depression and response to antidepressants.
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Name(s): Duclot, Florian, author
Kabbaj, Mohamed, author
Type of Resource: text
Genre: Journal Article
Text
Date Issued: 2015-01-01
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: Major depressive disorder (MDD) is a devastating neuropsychiatric disorder encompassing a wide range of cognitive and emotional dysfunctions. The prevalence of MDD is expected to continue its growth to become the second leading cause of disease burden (after HIV) by 2030. Despite an extensive research effort, the exact etiology of MDD remains elusive and the diagnostics uncertain. Moreover, a marked inter-individual variability is observed in the vulnerability to develop depression, as well as in response to antidepressant treatment, for nearly 50% of patients. Although a genetic component accounts for some cases of MDD, it is now clearly established that MDD results from strong gene and environment interactions. Such interactions could be mediated by epigenetic mechanisms, defined as chromatin and DNA modifications that alter gene expression without changing the DNA structure itself. Some epigenetic mechanisms have recently emerged as particularly relevant molecular substrates, promoting vulnerability or resilience to the development of depressive-like symptoms. Although the role of brain-derived neurotrophic factor (BDNF) in the pathophysiology of MDD remains unclear, its modulation of the efficacy of antidepressants is clearly established. Therefore, in this review, we focus on the epigenetic mechanisms regulating the expression of BDNF in humans and in animal models of depression, and discuss their role in individual differences in vulnerability to depression and response to antidepressant drugs.
Identifier: FSU_pmch_25568448 (IID), 10.1242/jeb.107086 (DOI), PMC4286703 (PMCID), 25568448 (RID), 25568448 (EID), 218/1/21 (PII)
Keywords: BDNF, Epigenetics, Individual differences
Grant Number: R01 MH087583, R01 MH099085, R21 MH081046, R21 MH083128
Publication Note: This NIH-funded author manuscript originally appeared in PubMed Central at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4286703.
Subject(s): Animals
Antidepressive Agents/pharmacology
Antidepressive Agents/therapeutic use
Brain-Derived Neurotrophic Factor/genetics
Depression/drug therapy
Depression/genetics
Disease Models, Animal
Epigenesis, Genetic/drug effects
Genetic Predisposition to Disease
Humans
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_pmch_25568448
Owner Institution: FSU
Is Part Of: The Journal of experimental biology.
1477-9145
Issue: iss. Pt 1, vol. 218

Choose the citation style.
Duclot, F., & Kabbaj, M. (2015). Epigenetic mechanisms underlying the role of brain-derived neurotrophic factor in depression and response to antidepressants. The Journal Of Experimental Biology. Retrieved from http://purl.flvc.org/fsu/fd/FSU_pmch_25568448