You are here
Epigenetic mechanisms underlying the role of brain-derived neurotrophic factor in depression and response to antidepressants.
Title: | Epigenetic mechanisms underlying the role of brain-derived neurotrophic factor in depression and response to antidepressants. |
![]() ![]() |
---|---|---|
Name(s): |
Duclot, Florian, author Kabbaj, Mohamed, author |
|
Type of Resource: | text | |
Genre: |
Journal Article Text |
|
Date Issued: | 2015-01-01 | |
Physical Form: |
computer online resource |
|
Extent: | 1 online resource | |
Language(s): | English | |
Abstract/Description: | Major depressive disorder (MDD) is a devastating neuropsychiatric disorder encompassing a wide range of cognitive and emotional dysfunctions. The prevalence of MDD is expected to continue its growth to become the second leading cause of disease burden (after HIV) by 2030. Despite an extensive research effort, the exact etiology of MDD remains elusive and the diagnostics uncertain. Moreover, a marked inter-individual variability is observed in the vulnerability to develop depression, as well as in response to antidepressant treatment, for nearly 50% of patients. Although a genetic component accounts for some cases of MDD, it is now clearly established that MDD results from strong gene and environment interactions. Such interactions could be mediated by epigenetic mechanisms, defined as chromatin and DNA modifications that alter gene expression without changing the DNA structure itself. Some epigenetic mechanisms have recently emerged as particularly relevant molecular substrates, promoting vulnerability or resilience to the development of depressive-like symptoms. Although the role of brain-derived neurotrophic factor (BDNF) in the pathophysiology of MDD remains unclear, its modulation of the efficacy of antidepressants is clearly established. Therefore, in this review, we focus on the epigenetic mechanisms regulating the expression of BDNF in humans and in animal models of depression, and discuss their role in individual differences in vulnerability to depression and response to antidepressant drugs. | |
Identifier: | FSU_pmch_25568448 (IID), 10.1242/jeb.107086 (DOI), PMC4286703 (PMCID), 25568448 (RID), 25568448 (EID), 218/1/21 (PII) | |
Keywords: | BDNF, Epigenetics, Individual differences | |
Grant Number: | R01 MH087583, R01 MH099085, R21 MH081046, R21 MH083128 | |
Publication Note: | This NIH-funded author manuscript originally appeared in PubMed Central at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4286703. | |
Subject(s): |
Animals Antidepressive Agents/pharmacology Antidepressive Agents/therapeutic use Brain-Derived Neurotrophic Factor/genetics Depression/drug therapy Depression/genetics Disease Models, Animal Epigenesis, Genetic/drug effects Genetic Predisposition to Disease Humans |
|
Persistent Link to This Record: | http://purl.flvc.org/fsu/fd/FSU_pmch_25568448 | |
Owner Institution: | FSU | |
Is Part Of: |
The Journal of experimental biology. 1477-9145 |
|
Issue: | iss. Pt 1, vol. 218 |
Duclot, F., & Kabbaj, M. (2015). Epigenetic mechanisms underlying the role of brain-derived neurotrophic factor in depression and response to antidepressants. The Journal Of Experimental Biology. Retrieved from http://purl.flvc.org/fsu/fd/FSU_pmch_25568448