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Function of microglia and macrophages in secondary damage after spinal cord injury.

Title: Function of microglia and macrophages in secondary damage after spinal cord injury.
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Name(s): Zhou, Xiang, author
He, Xijing, author
Ren, Yi, author
Type of Resource: text
Genre: Journal Article
Text
Date Issued: 2014-10-15
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: Spinal cord injury (SCI) is a devastating type of neurological trauma with limited therapeutic opportunities. The pathophysiology of SCI involves primary and secondary mechanisms of injury. Among all the secondary injury mechanisms, the inflammatory response is the major contributor and results in expansion of the lesion and further loss of neurologic function. Meanwhile, the inflammation directly and indirectly dominates the outcomes of SCI, including not only pain and motor dysfunction, but also preventingneuronal regeneration. Microglia and macrophages play very important roles in secondary injury. Microglia reside in spinal parenchyma and survey the microenvironment through the signals of injury or infection. Macrophages are derived from monocytes recruited to injured sites from the peripheral circulation. Activated resident microglia and monocyte-derived macrophages induce and magnify immune and inflammatory responses not only by means of their secretory moleculesand phagocytosis, but also through their influence on astrocytes, oligodendrocytes and demyelination. In this review, we focus on the roles of microglia and macrophages in secondary injury and how they contribute to the sequelae of SCI.
Identifier: FSU_pmch_25422640 (IID), 10.4103/1673-5374.143423 (DOI), PMC4239768 (PMCID), 25422640 (RID), 25422640 (EID), NRR-9-1787 (PII)
Keywords: M1/M2 activation, Astrocytes, Chemokines, Cytokines, Demyelination, Inflammation, Macrophages, Microglia, Oligodendrocytes, Secondary damage, Spinal cord injury
Grant Number: R01 GM100474
Publication Note: This NIH-funded author manuscript originally appeared in PubMed Central at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4239768.
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_pmch_25422640
Owner Institution: FSU
Is Part Of: Neural regeneration research.
1673-5374
Issue: iss. 20, vol. 9

Choose the citation style.
Zhou, X., He, X., & Ren, Y. (2014). Function of microglia and macrophages in secondary damage after spinal cord injury. Neural Regeneration Research. Retrieved from http://purl.flvc.org/fsu/fd/FSU_pmch_25422640