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Title: Spermitin: a novel mitochondrial protein in Drosophila spermatids.
Name(s): Chen, Jieyan V, author
Megraw, Timothy L, author
Type of Resource: text
Genre: Journal Article
Date Issued: 2014-09-29
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: Mitochondria, important energy centers in the cell, also control sperm cell morphogenesis. Drosophila spermatids have a remarkably large mitochondrial formation called the nebenkern. Immediately following meiosis during sperm development, the mitochondria in the spermatid fuse together into two large aggregates which then wrap around one another to produce the spherical nebenkern: a giant mitochondrion about 6 micrometers in diameter. The fused mitochondria play an important role in sperm tail elongation by providing a structural platform to support the elongation of sperm cells. We have identified a novel testis-specific protein, Spermitin (Sprn), a protein with a Pleckstrin homology-like (PH) domain related to Ran-binding protein 1 at its C-terminus. Fluorescence microscopy showed that Sprn localizes at mitochondria in transfected Kc167 cells, and in the nebenkern throughout spermatid morphogenesis. The role of Sprn is unclear, as sprn mutant males are fertile, and have sperm tail length comparable to the wild-type.
Identifier: FSU_pmch_25265054 (IID), 10.1371/journal.pone.0108802 (DOI), PMC4181656 (PMCID), 25265054 (RID), 25265054 (EID), PONE-D-14-12211 (PII)
Grant Number: GM068756
Publication Note: This NIH-funded author manuscript originally appeared in PubMed Central at
Subject(s): Animals
Drosophila Proteins/metabolism
Drosophila melanogaster/metabolism
Green Fluorescent Proteins/metabolism
Mitochondrial Proteins/metabolism
Organ Specificity
Protein Transport
Recombinant Fusion Proteins/metabolism
Sperm Tail/metabolism
Persistent Link to This Record:
Owner Institution: FSU
Is Part Of: PloS one.
Issue: iss. 9, vol. 9

Choose the citation style.
Chen, J. V., & Megraw, T. L. (2014). Spermitin: a novel mitochondrial protein in Drosophila spermatids. Plos One. Retrieved from