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14-3-3 proteins are required for hippocampal long-term potentiation and associative learning and memory.

Title: 14-3-3 proteins are required for hippocampal long-term potentiation and associative learning and memory.
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Name(s): Qiao, Haifa, author
Foote, Molly, author
Graham, Kourtney, author
Wu, Yuying, author
Zhou, Yi, author
Type of Resource: text
Genre: Journal Article
Text
Date Issued: 2014-04-02
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: 14-3-3 is a family of regulatory proteins highly expressed in the brain. Previous invertebrate studies have demonstrated the importance of 14-3-3 in the regulation of synaptic functions and learning and memory. However, the in vivo role of 14-3-3 in these processes has not been determined using mammalian animal models. Here, we report the behavioral and electrophysiological characterization of a new animal model of 14-3-3 proteins. These transgenic mice, considered to be a 14-3-3 functional knock-out, express a known 14-3-3 inhibitor in various brain regions of different founder lines. We identify a founder-specific impairment in hippocampal-dependent learning and memory tasks, as well as a correlated suppression in long-term synaptic plasticity of the hippocampal synapses. Moreover, hippocampal synaptic NMDA receptor levels are selectively reduced in the transgenic founder line that exhibits both behavioral and synaptic plasticity deficits. Collectively, our findings provide evidence that 14-3-3 is a positive regulator of associative learning and memory at both the behavioral and cellular level.
Identifier: FSU_pmch_24695700 (IID), 10.1523/JNEUROSCI.4393-13.2014 (DOI), PMC3972712 (PMCID), 24695700 (RID), 24695700 (EID), 34/14/4801 (PII)
Keywords: 14-3-3 proteins, NMDA receptors, Fear conditioning, Long-term potentiation, Passive avoidance
Grant Number: R01 NS050355, NS50355
Publication Note: This NIH-funded author manuscript originally appeared in PubMed Central at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3972712.
Subject(s): 14-3-3 Proteins/deficiency
14-3-3 Proteins/physiology
Animals
Association Learning/physiology
Avoidance Learning/physiology
Bacterial Proteins/genetics
Bacterial Proteins/metabolism
Conditioning (Psychology)/physiology
Electric Stimulation
Excitatory Postsynaptic Potentials/genetics
Fear/physiology
Hippocampus/metabolism
Hippocampus/physiology
In Vitro Techniques
Long-Term Potentiation/genetics
Long-Term Potentiation/physiology
Luminescent Proteins/genetics
Luminescent Proteins/metabolism
Memory/physiology
Mice
Mice, Inbred C57BL
Mice, Transgenic
Patch-Clamp Techniques
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_pmch_24695700
Owner Institution: FSU
Is Part Of: The Journal of neuroscience : the official journal of the Society for Neuroscience.
1529-2401
Issue: iss. 14, vol. 34

Choose the citation style.
Qiao, H., Foote, M., Graham, K., Wu, Y., & Zhou, Y. (2014). 14-3-3 proteins are required for hippocampal long-term potentiation and associative learning and memory. The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience. Retrieved from http://purl.flvc.org/fsu/fd/FSU_pmch_24695700